JavaScript NENÍ povolen !

Prosím povolte JavaScript.

* Zobrazit nápovědu

Reset

Autor: Toledo, Jon B

2 záznamů v Medvik Filtry

Článek

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

Kovacs, Gabor G
Autor Kovacs, Gabor G Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada
Xie, Sharon X
Autor Xie, Sharon X Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada
Lee, Edward B
Autor Lee, Edward B Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada
Robinson, John L
Autor Robinson, John L Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada
Caswell, Carrie
Autor Caswell, Carrie Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada
Irwin, David J
Autor Irwin, David J Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada
Toledo, Jon B
Autor Toledo, Jon B Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada
Johnson, Victoria E
Autor Johnson, Victoria E Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada
Smith, Douglas H
Autor Smith, Douglas H Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada
Alafuzoff, Irina
Autor Alafuzoff, Irina Institute of Neurology, Medical University of Vienna, Vienna, Austria Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania and Department of Biostatistics and Epidemiology and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain Department of Medicine, Imperial College London, London, UK IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy Memory and Aging Center, Department of Neurology, University of California, San Francisco, California Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York Department of Neuropathology, John Radcliffe Hospital, Oxford, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan Department of Neuroscience, Katholieke Universiteit-Leuven and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada

Journal of neuropathology and experimental neurology. 2017 ; 76 (7) : 605-619.

J Neuropathol Exp Neurol
ISSN 1554-6578
Medvik
Zdroj

Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was >60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (>90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.

Článek

Acta neuropathologica. 2016 ; 131 (1) : 87-102. [pub] 20151210

Acta Neuropathol
ISSN 1432-0533
Medvik
Zdroj

Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.

MeSH
astrocyty cytologie MeSH
lidé MeSH
mozek metabolismus patologie MeSH
neuroglie patologie MeSH
proteiny tau metabolismus MeSH
stárnutí * MeSH
tauopatie metabolismus patologie MeSH
zvířata MeSH
Check Tag
lidé MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
přehledy MeSH
Research Support, N.I.H., Extramural MeSH
Research Support, U.S. Gov't, Non-P.H.S. MeSH

Kolekce

Publikováno

Filtry

* Zobrazit nápovědu

* Zobrazit nápovědu

Upřesnit dle MeSH