Tablets
Dotaz
Zobrazit nápovědu
- Klíčová slova
- PHARMACY *, TABLETS *,
- MeSH
- farmacie * MeSH
- lékárny * MeSH
- tablety * MeSH
- tobolky * MeSH
- želatina * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- tablety * MeSH
- tobolky * MeSH
- želatina * MeSH
Tablets are the most frequently employed dosage form. Their advantage lies in their availability, easy administration, good stability, and low price. The easiest technology to produce tablets is direct compression, even though the use of the method requires overcoming many obstacles, mainly related to content uniformity and variation of mass, disintegration, dissolution, and radial hardness of tablets. “Co-processed excipients”, containing commonly processed blends of fillers, binders, disintegrants, lubricants, and other excipients are more and more widely used nowadays. These mixtures are manufactured by various technologies, chiefly by spray-drying, fluid bed granulation, wet granulation, melt granulation, dry granulation, and co-crystallisation. This review article lists excipients used usually to constitute co-processed excipients, technologies, and commercially available co-processed excipients for direct compression.
- Klíčová slova
- co-processed excipients, direct compression, blends, tablets, physical characteristics,
- MeSH
- farmaceutická technologie MeSH
- pomocné látky * MeSH
- rozpustnost MeSH
- tablety * MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- pomocné látky * MeSH
- tablety * MeSH
- Klíčová slova
- CHEMISTRY, PHARMACEUTICAL *, TABLETS *, TALC *,
- MeSH
- farmaceutická chemie * MeSH
- mastek * MeSH
- prášky, zásypy, pudry * MeSH
- tablety * MeSH
- tření * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- mastek * MeSH
- prášky, zásypy, pudry * MeSH
- tablety * MeSH
- Klíčová slova
- CHEMISTRY, PHARMACEUTICAL *, TABLETS *,
- MeSH
- farmaceutická chemie * MeSH
- farmacie * MeSH
- tablety * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- tablety * MeSH
- Klíčová slova
- AMINOPYRINE *, GELATIN *, STARCH *, TABLETS *,
- MeSH
- aminopyrin * MeSH
- škrob * MeSH
- tablety * MeSH
- želatina * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- aminopyrin * MeSH
- škrob * MeSH
- tablety * MeSH
- želatina * MeSH
Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim of this study was to evaluate the rheological and compression properties of lubricated mixtures of co-processed dry binders Parteck® ODT, Prosolv® ODT G2 and Ludiflash®, and subsequently also the compactability and disintegration time of the tablets made thereof. The lubricants employed were magnesium stearate and sodium stearyl fumarate in the concentrations of 0.5% and 1%. The best flowability was shown by Prosolv® ODT G2 combined with magnesium stearate in the concentration of 0.5%. Lubricated mixtures with Prosolv® ODT G2 showed a lower angle of internal friction as well as lower pre-compression energy values. The values of plastic deformation energy were the highest in the case of Prosolv® ODT G2, which was also reflected in the highest tablet strength. On the contrary, the ejection force values were the lowest for this co-processed dry binder. Magnesium stearate reduced the ejection force more effectively than sodium stearyl fumarate. Prosolv® ODT G2 tablets exhibited the highest tensile strength and shortest disintegration time.
- Klíčová slova
- Co-processed dry binders, Compactability, Disintegration time, Energy profile of compression, Flow properties, Orally disintegrating tablets,
- MeSH
- lubrikanty * MeSH
- pevnost v tahu MeSH
- pomocné látky * MeSH
- tablety MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- lubrikanty * MeSH
- pomocné látky * MeSH
- tablety MeSH
- Klíčová slova
- ANALGESICS *, TABLETS *,
- MeSH
- analgetika * MeSH
- tablety * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- analgetika * MeSH
- tablety * MeSH
