5Institute of Molecular Biomedicine Faculty of Medicine Comenius University Bratislava Slovakia 6Institute of Physiology Academy of Sciences of the Czech Republic Praha Czech Republic

Centre for Cardiovascular Research Prague Czech Republic

Comenius University Faculty of Medicine Department of Pathophysiology Bratislava Slovakia

CRC and Institute of Physiology Academy of Sciences of the Czech Republic Prague Czech Republic

Department of Experimental Hypertension Institute of Physiology Academy of Sciences of the Czech Republic Prague Czech Republic

Department of Experimental hypertension Institute of Physiology CAS Prague Czech Republic

Department of Experimental Hypertension Institute of Physiology Czech Academy of Sciences Prague Czech Republic

Department of Experimental Hypertension Institute of Physiology of the Czech Academy of Sciences Prague Czech Republic

Department of Pathophysiology Faculty of Medicine Comenius University Bratislava Slovakia

Experimental Hypertension Institute of Physiology Czech Academy of Sciences Prague

From the Department of Experimental Hypertension Institute of Physiology Czech Academy of Sciences Prague

Fyziologický ústav

Institute of Physiology Academy of Sciences of the Czech Republic 14220 Prague 4 Czech Republic

Institute of Physiology Academy of Sciences of the Czech Republic Prague Czech Republic

Institute of Physiology Academy of Sciences of the Czech Republic Prague Czech Republic bInstitute of Pharmacology Faculty of Medicine Comenius University Bratislava Slovakia *Michal Behuliak and Mária Pintérová contributed equally to the writing of this article

Institute of Physiology Academy of Sciences of the Czech Republic Videnská 1083 CZ 14220 Prague 4 Czech Republic

Institute of Physiology CAS Prague Czech Republic

Institute of Physiology Czech Academy of Sciences 14220 Prague Czech Republic

Institute of Physiology Czech Academy of Sciences bDepartment of Physiology Faculty of Sciences Charles University Prague Czech Republic

Institute of Physiology Czech Academy of Sciences Prague 4 Czech Republic

Institute of Physiology Czech Academy of Sciences Prague Czech Republic

Institute of Physiology Czech Academy of Sciences Prague Czechia

Institute of Physiology of the Czech Academy of Sciences Prague

Institute of Physiology of the Czech Academy of Sciences Prague Czech Republic

Institute of PhysiologyAcademy of Sciences of the Czech Republic v v i Videnska 1083 14220 Prague 4 Czech RepublicInstitute of Organic Chemistry and BiochemistryAcademy of Sciences of the Czech Republic v v i Prague Czech Republic

Laboratory of Experimental Hypertension Institute of Physiology of the Czech Academy of Sciences Prague Czech Republic

Virologický ústav SAV Bratislava Slovenská Republika