• MeSH
• Apoptosis physiology   MeSH
• Cell Death MeSH
• Publication type
• Monograph MeSH

• Conspectus
• Buněčná biologie. Cytologie
• NML Fields
• cytologie, klinická cytologie
• biologie

"Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This pathological dysregulation of cell death can be characterized by either too much loss of essential cells in the heart, brain, and other tissues with little regenerative capacity or by too little cell turnover in self-renewing tissues, giving rise to cancer and other maladies. This is a process of fundamental importance for development and normal health, which is altered in many disease conditions. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis"--Provided by publisher.

Liter. na konci kapitol

Machine generated contents note: Part I. General Principles of Cell Death: 1. Human caspases - apoptosis and inflammation signaling proteases Guy S. Salvesen; 2. Inhibitor of apoptosis proteins Jason B. Garrison, Andreas Krieg, Kate Welsh, Yunfei Wen, and John C. Reed; 3. Death domain-containing receptors: decisions between suicide and fire Henning Walczak and Chahrazade Kantari; 4. Mitochondria and cell death Gavin P. McStay and Douglas R. Green; 5. BCL-2 family proteins and the control of mitochondrial apoptosis Anthony Letai; 6. Endoplasmic reticulum stress response in cell death and cell survival Michael Boyce, Marta M. Lipinski, Be;ne;dicte F. Py and Junying Yuan; 7. Autophagy: the liaison between the lysosomal system and cell death Hiroshi Koga and Ana Maria Cuervo; 8. Cell death in response to genotoxic stress and DNA damage Pablo Lopez-Bergami and Ze'ev Ronai; 9. Ceramide and lipid mediators in apoptosis Thomas D. Mullen, Russell W. Jenkins, Lina M. Obeid, and Yusuf A. Hannun; 10. Cytotoxic granules house potent pro-apoptotic toxins critical for anti-viral responses and immune homeostasis Katherine Baran, Ilia Voskoboinik, Nigel J. Waterhouse, Vivien R. Sutton and Joseph A. Trapani; Part II. Cell Death in Tissues and Organs: 11. Cell death in nervous system development and neurological disease Juying Li and Junying Yuan; 12. Role of programmed cell death in neurodegenerative diseases Dale E. Bredesen; 13. Implications of nitrosative stress-induced protein misfolding in neurodegeneration Tomohiro Nakamura and Stuart A. Lipton; 14. Mitochondrial mechanisms of neural cell death in cerebral ischemia Lucian Soane, Brian M. Polster, and Gary Fiskum; 15. Cell death In spinal cord injury: an evolving taxonomy with therapeutic promise Rajiv R. Ratan and Moses V. Chao; 16. Apoptosis and homeostasis in the eye Jerry Y. Niederkorn; 17. Cell death in the inner ear Lisa L. Cunningham and Justin Tan; Machine generated contents note: Part I. General Principles of Cell Death: 1. Human caspases - apoptosis and inflammation signaling proteases Guy S. Salvesen; 2. Inhibitor of apoptosis proteins Jason B. Garrison, Andreas Krieg, Kate Welsh, Yunfei Wen, and John C. Reed; 3. Death domain-containing receptors: decisions between suicide and fire Henning Walczak and Chahrazade Kantari; 4. Mitochondria and cell death Gavin P. McStay and Douglas R. Green; 5. BCL-2 family proteins and the control of mitochondrial apoptosis Anthony Letai; 6. Endoplasmic reticulum stress response in cell death and cell survival Michael Boyce, Marta M. Lipinski, Be;ne;dicte F. Py and Junying Yuan; 7. Autophagy: the liaison between the lysosomal system and cell death Hiroshi Koga and Ana Maria Cuervo; 8. Cell death in response to genotoxic stress and DNA damage Pablo Lopez-Bergami and Ze'ev Ronai; 9. Ceramide and lipid mediators in apoptosis Thomas D. Mullen, Russell W. Jenkins, Lina M. Obeid, and Yusuf A. Hannun; 10. Cytotoxic granules house potent pro-apoptotic toxins critical for anti-viral responses and immune homeostasis Katherine Baran, Ilia Voskoboinik, Nigel J. Waterhouse, Vivien R. Sutton and Joseph A. Trapani; Part II. Cell Death in Tissues and Organs: 11. Cell death in nervous system development and neurological disease Juying Li and Junying Yuan; 12. Role of programmed cell death in neurodegenerative diseases Dale E. Bredesen; 13. Implications of nitrosative stress-induced protein misfolding in neurodegeneration Tomohiro Nakamura and Stuart A. Lipton; 14. Mitochondrial mechanisms of neural cell death in cerebral ischemia Lucian Soane, Brian M. Polster, and Gary Fiskum; 15. Cell death In spinal cord injury: an evolving taxonomy with therapeutic promise Rajiv R. Ratan and Moses V. Chao; 16. Apoptosis and homeostasis in the eye Jerry Y. Niederkorn; 17. Cell death in the inner ear Lisa L. Cunningham and Justin Tan;