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Akutní toxicita prvků vzácných zemin a jejich sloučenin
[Acute toxicity of rare earth elements and their compounds]
Robert Filipi, Karel Nesměrák, Marian Rucki, Zdeněk Roth, Iveta Hanzlíková, Miloň Tichý
Language Czech Country Czech Republic
- MeSH
- Metals, Rare Earth toxicity MeSH
- Quantitative Structure-Activity Relationship MeSH
- Lethal Dose 50 MeSH
- Mice MeSH
- Toxicity Tests MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
Acute toxicity of chlorides of rare earth elements has been determined as EC50 for movement inhibition of oligochaeta Tubifex tubifex, EC50(T.t.). There is no statistically significant difference among EC50 values for the rare earth chlorides. Their QSAR is: EC50(T.t.) = 0.0781 ± 0.0058 (mol l-1) (n=14) and log EC50(T.t.) = -1.107, corresponding to the fact that there is also no sigChem. Listy 101, 793-798 (2007) Laboratorní přístroje a postupy 798 nificant difference in the values of their physicochemical properties. The EC50(T.t.) values are comparable with those of, e.g., BaCl2 or CdCl2 classified as toxic compounds. Thus, the EC50(T.t.) indicates the hazard of rare earth salts for aqueous environment as well. The literature search shows that usage and waste of rare earth elements and their compounds are increasing. Several laboratory findings indicate their possible influence on calcium metabolism in organisms.
Acute toxicity of rare earth elements and their compounds
Lit.: 39
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- $a Acute toxicity of rare earth elements and their compounds
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- $a Přírodovědecká fakulta UK, Praha 2
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- $a Acute toxicity of chlorides of rare earth elements has been determined as EC50 for movement inhibition of oligochaeta Tubifex tubifex, EC50(T.t.). There is no statistically significant difference among EC50 values for the rare earth chlorides. Their QSAR is: EC50(T.t.) = 0.0781 ± 0.0058 (mol l-1) (n=14) and log EC50(T.t.) = -1.107, corresponding to the fact that there is also no sigChem. Listy 101, 793-798 (2007) Laboratorní přístroje a postupy 798 nificant difference in the values of their physicochemical properties. The EC50(T.t.) values are comparable with those of, e.g., BaCl2 or CdCl2 classified as toxic compounds. Thus, the EC50(T.t.) indicates the hazard of rare earth salts for aqueous environment as well. The literature search shows that usage and waste of rare earth elements and their compounds are increasing. Several laboratory findings indicate their possible influence on calcium metabolism in organisms.
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