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The effect of low dose of vinclozolin on reproductive tract development in CD1 outbred mice
Peknicova J., Elzeinova F., Novakova V., Buckiova D., Kubatova A.
Status not-indexed Language English Country Czech Republic
Document type Abstracts
The effect of low dose of fungicide vinclozolin within development of reproductive tract during gestation (GD) and puberty (PND) in outbred CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Marked negative influence has had on sperm parameters. Sperm counts decreased to 46% (GD) and to 81% (PND) and also acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to control group (100%). Sperm head abnormalities increased about 18% and 13%, respectively. In this connection the expression some genes was changed (arosome– related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups. The work was supported by the Grants of the Ministry of Education of the Czech Republic, grant No. 1M06011 and 2B06151 and in part by the Institutional Research Support AVOZ 50520701.
3. český a mezinárodní andrologický kongres, Štiřín, 13.-15.6.2008
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- $a The effect of low dose of fungicide vinclozolin within development of reproductive tract during gestation (GD) and puberty (PND) in outbred CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Marked negative influence has had on sperm parameters. Sperm counts decreased to 46% (GD) and to 81% (PND) and also acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to control group (100%). Sperm head abnormalities increased about 18% and 13%, respectively. In this connection the expression some genes was changed (arosome– related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups. The work was supported by the Grants of the Ministry of Education of the Czech Republic, grant No. 1M06011 and 2B06151 and in part by the Institutional Research Support AVOZ 50520701.
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