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Porcine OGN and ASPN: mapping, polymorphisms and use for quantitative trait loci identification for growth and carcass traits in a Meishan x Piétrain intercross
Stratil A., Van Poucke M., Bartenschlager H., Knoll A., Yerle M., Peelman L.J., Kopecný M., Geldermann H.
Language English Country Great Britain
Document type Comparative Study
NLK
Medline Complete (EBSCOhost)
from 1998-02-01 to 1 year ago
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
- MeSH
- Financing, Organized MeSH
- Glycoproteins genetics MeSH
- Polymorphism, Single Nucleotide MeSH
- Crosses, Genetic MeSH
- Humans MeSH
- Quantitative Trait Loci MeSH
- Chromosome Mapping MeSH
- Intercellular Signaling Peptides and Proteins MeSH
- Microsatellite Repeats MeSH
- Swine genetics growth & development MeSH
- Proteoglycans genetics MeSH
- Synteny MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Comparative Study MeSH
The porcine orthologues of human chromosome HSA9q22.31 genes osteoglycin (OGN) and asporin (ASPN) were mapped to porcine chromosome SSC3 using linkage analysis and a somatic cell hybrid panel. This mapping was refined to SSC3q11 using fluorescence in situ hybridization. These results confirm the existence of a small conserved synteny group between SSC3 and HSA9. Polymorphisms were revealed in both genes, including a pentanucleotide microsatellite (SCZ003) in OGN and two single nucleotide polymorphisms (AM181682.1:g.780G>T and AM181682.1:g.825T>C) in ASPN. The two genes were included in a set of markers for quantitative trait loci (QTL) mapping on SSC3 in the Hohenheim Meishan x Piétrain F2 family. Major QTL for growth and carcass traits were centred in the ASPN-SW902 region.
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- 090512s2006 xxk e eng||
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- $a Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 277 21 Libechov, Czech Republic. stratil@iapg.cas.cz
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- $a The porcine orthologues of human chromosome HSA9q22.31 genes osteoglycin (OGN) and asporin (ASPN) were mapped to porcine chromosome SSC3 using linkage analysis and a somatic cell hybrid panel. This mapping was refined to SSC3q11 using fluorescence in situ hybridization. These results confirm the existence of a small conserved synteny group between SSC3 and HSA9. Polymorphisms were revealed in both genes, including a pentanucleotide microsatellite (SCZ003) in OGN and two single nucleotide polymorphisms (AM181682.1:g.780G>T and AM181682.1:g.825T>C) in ASPN. The two genes were included in a set of markers for quantitative trait loci (QTL) mapping on SSC3 in the Hohenheim Meishan x Piétrain F2 family. Major QTL for growth and carcass traits were centred in the ASPN-SW902 region.
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