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A new model of severe neurogenic pulmonary edema in spinal cord injured rat
Jiří Šedý, Lucia Urdzíková, Katarína Likavčanová, Aleš Hejčl, Pavla Jendelová, Eva Syková
Language English Country Ireland
Grant support
1A8697
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Anesthetics, Inhalation administration & dosage MeSH
- Financing, Organized MeSH
- Isoflurane administration & dosage MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Pulmonary Edema etiology pathology MeSH
- Spinal Cord Injuries complications MeSH
- Rats, Wistar MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
We describe a new model of neurogenic pulmonary edema in spinal cord injured Wistar male rats. The pulmonary edema was elicited by an epidural thoracic balloon compression spinal cord lesion, performed under a low concentration of isoflurane (1.5 or 2%) in air. Anesthesia with 1.5% isoflurane promoted very severe interstitial and intraalveolar neurogenic pulmonary edema with a significantly increased thickness of the alveolar walls and massive pulmonary hemorrhage. In this group, 33% of animals died. Anesthesia with 2% isoflurane promoted severe interstitial and intraalveolar neurogenic pulmonary edema with less thickening of the alveolar walls and pulmonary hemorrhage. For evoking severe neurogenic pulmonary edema in spinal cord injured rats, 2% isoflurane anesthesia would be more suitable. However, if very severe neurogenic pulmonary edema needs to be evoked, spinal cord injury under 1.5% isoflurane anesthesia could be used, but one-third of the animals will be lost.
Department of Neuroscience 2nd Faculty of Medicine Charles University Prague Czech Republic
Institute of Experimental Medicine ASCR Prague Czech Republic
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- $a A new model of severe neurogenic pulmonary edema in spinal cord injured rat / $c Jiří Šedý, Lucia Urdzíková, Katarína Likavčanová, Aleš Hejčl, Pavla Jendelová, Eva Syková
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