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Inhibition of blood and tissue cholinesterases by soman in guinea pigs in vivo

Jiri Bajgar, Jiri Kassa, Miroslav Pohanka, Jana Zdarova Karasova, Ladislav Novotny, Josef Fusek, Vaclav Blaha

. 2011 ; 9 (1) : 35-41.

Language English Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc11003535

Guinea pigs were intoxicated intramuscularly with different doses of soman, and cholinesterase activities were determined in the blood, diaphragm and parts of the brain - the pontomedullar area, the frontal cortex and the basal ganglia. The time course of poisoning following low doses (1,3, 5 microg/kg) and a dose equal to 1xLD50 (28.5 microg/kg) were studied. The dose having a negligible effect on cholinesterases in the tissues studied was assessed at 1-3 microg/kg, and, following administration of a dose of 5 microg/kg, statistically significant blood cholinesterase inhibition was demonstrated.

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Lit.: 33

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$a Guinea pigs were intoxicated intramuscularly with different doses of soman, and cholinesterase activities were determined in the blood, diaphragm and parts of the brain - the pontomedullar area, the frontal cortex and the basal ganglia. The time course of poisoning following low doses (1,3, 5 microg/kg) and a dose equal to 1xLD50 (28.5 microg/kg) were studied. The dose having a negligible effect on cholinesterases in the tissues studied was assessed at 1-3 microg/kg, and, following administration of a dose of 5 microg/kg, statistically significant blood cholinesterase inhibition was demonstrated.
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