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Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid
M Stiborova, E Frei, HH Schmeiser
Language English Country United States
Document type Comment
NLK
Free Medical Journals
from 1972 to 2011
Freely Accessible Science Journals
from 1972
ProQuest Central
from 2000-01-01 to 2015-12-31
Open Access Digital Library
from 1972-01-01
Nursing & Allied Health Database (ProQuest)
from 2000-01-01 to 2015-12-31
Health & Medicine (ProQuest)
from 2000-01-01 to 2015-12-31
PubMed
18480852
DOI
10.1038/ki.2008.125
Knihovny.cz E-resources
- MeSH
- Liver enzymology MeSH
- Carcinogens metabolism toxicity MeSH
- Aristolochic Acids metabolism toxicity MeSH
- Inactivation, Metabolic MeSH
- Mice MeSH
- NADPH-Ferrihemoprotein Reductase genetics metabolism MeSH
- Kidney Diseases enzymology chemically induced MeSH
- Urologic Neoplasms enzymology chemically induced MeSH
- Urothelium MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Comment MeSH
Ingestion of aristolochic acid (AA) is associated with the development of AA-nephropathy and Balkan endemic nephropathy, which are characterized by chronic renal failure, tubulointerstitial fibrosis, and urothelial cancer. Understanding which enzymes are involved in AA activation and/or detoxification is important in assessing susceptibility to AA. Xiao et al. demonstrate that hepatic cytochrome P450s in mice detoxicate AA and thereby protect kidney from injury. The relative contribution of enzymes activating AA to induce urothelial cancer in humans remains to be resolved.
References provided by Crossref.org
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