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Syntéza proteinkinasových inhibitorů [Synthesis of protein kinase inhibitors]

Francesca Scarpitta, Augusto Canavesi, Alexandr Jegorov

. 2011 ; 105 (4) : 278-281.

Language Czech Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc11031302

Two procedures have been developed for the synthesis of sorafenib tosylate. The aim of the development was to minimize production of symmetric ureas in the course of synthesis, which create the major impurities of the preceeding processes and are difficult to remove. The major achievements were the purity of sorafenib thus obtained (> 99.8 %, HPLC) and possibility to scale up the syntheses.

Synthesis of protein kinase inhibitors

Bibliography, etc.

Lit.: 9

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