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Nucleolar transplantation in oocytes and zygotes: challenges for further research
H Fulka, J Jr Fulka
Language English Country Great Britain
Document type Research Support, Non-U.S. Gov't, Review
NLK
Free Medical Journals
from 1996 to 1 year ago
Open Access Digital Library
from 1996-01-01
Medline Complete (EBSCOhost)
from 1995-01-01 to 1 year ago
- MeSH
- Reproductive Techniques, Assisted MeSH
- Cell Nucleolus transplantation MeSH
- Embryo, Mammalian cytology MeSH
- Humans MeSH
- Oocytes cytology MeSH
- Animals MeSH
- Zygote cytology MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
In germinal vesicles of immature mammalian oocytes, including humans, as well as in pronuclei in 1-cell stage embryos, prominent nuclear organelles, nucleoli, can be easily detected even under a relatively low magnification. In humans, it has been clearly documented that their number, position and distribution in pronuclei can be used as an indicator of embryonic developmental potential. In the light of some recent experiments showing the feasibility of nucleolar manipulation we discuss here if these new approaches can be used to rescue those embryos with abnormal pronuclear nucleolar patterns.
Literatura.
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