-
Something wrong with this record ?
Cognitive activities in the subthalamic nucleus. Invasive studies
I. Rektor, M. Baláž, M. Bočková
Language English Country Great Britain
Document type Research Support, Non-U.S. Gov't
- MeSH
- Electric Stimulation methods MeSH
- Electroencephalography methods MeSH
- Executive Function physiology MeSH
- Cognition physiology MeSH
- Humans MeSH
- Brain Mapping MeSH
- Cerebral Cortex physiology MeSH
- Neural Pathways physiology MeSH
- Subthalamic Nucleus physiology MeSH
- Parkinson Disease physiopathology therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: According to our studies, based on intracerebral recordings of cognitive Event Related Potentials (ERP), the cognitive activities in the the Basal Ganglia (BG) are organized in some way other than the well-known organization of the cortico-BG-thalamocortical circuits. PURPOSE: The cognitive role of the subthalamic nucleus (STN) has been largely unknown. Direct connections with the cortex that bypass the circuitries might underlie the processing of specific cognitive functions in the STN. STN seems to be specifically involved in the processing of some cognitive activities, e.g. of the executive functions. METHODS: A modified protocol with a dual task elicited local field ERP within the STN. Impact of cortical 1 Hz rTMS on STN was tested. ERD/S in was tested in visuomotor tasks with single letters writing. RESULTS: No generators of ERP (P3-like potentials) were elicited by the standard oddball protocol in the STN (at variance with recordings from the putamen, caudate and pallidum). rTMS over the right inferior frontal cortex caused a shortening of latencies of ERP in standard and dual protocols. No changes were observable after the rTMS over the dorzolateral prefrontal cortex and sham stimulation. In the STN, only the tasks with an increased demand on executive functions produced the alpha and beta ERD/S (event-related desynchronization/synchronization). CONCLUSION: Our results indicate a specific, task-related involvement of the STN in the cognitive activities. Cognitive processing in the STN is possibly processed via hyperdirect cortico-STN pathway. Certain effects of DBS surgery on cognitive performance could be explained by a direct effect on 'cognitive' parts of the STN.
- 000
- 03221naa a2200409 a 4500
- 001
- bmc12009126
- 003
- CZ-PrNML
- 005
- 20160414081140.0
- 008
- 120319s2009 xxk eng||
- 009
- AR
- 040 __
- $d ABA008 $a ABA008 $b cze
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Rektor, Ivan, $d 1948- $7 nlk19990073773 $u First Department of Neurology, Masaryk University, St. Anne's Hospital, Brno, Czech Republic. irektor@med.muni.cz
- 245 10
- $a Cognitive activities in the subthalamic nucleus. Invasive studies / $c I. Rektor, M. Baláž, M. Bočková
- 520 9_
- $a BACKGROUND: According to our studies, based on intracerebral recordings of cognitive Event Related Potentials (ERP), the cognitive activities in the the Basal Ganglia (BG) are organized in some way other than the well-known organization of the cortico-BG-thalamocortical circuits. PURPOSE: The cognitive role of the subthalamic nucleus (STN) has been largely unknown. Direct connections with the cortex that bypass the circuitries might underlie the processing of specific cognitive functions in the STN. STN seems to be specifically involved in the processing of some cognitive activities, e.g. of the executive functions. METHODS: A modified protocol with a dual task elicited local field ERP within the STN. Impact of cortical 1 Hz rTMS on STN was tested. ERD/S in was tested in visuomotor tasks with single letters writing. RESULTS: No generators of ERP (P3-like potentials) were elicited by the standard oddball protocol in the STN (at variance with recordings from the putamen, caudate and pallidum). rTMS over the right inferior frontal cortex caused a shortening of latencies of ERP in standard and dual protocols. No changes were observable after the rTMS over the dorzolateral prefrontal cortex and sham stimulation. In the STN, only the tasks with an increased demand on executive functions produced the alpha and beta ERD/S (event-related desynchronization/synchronization). CONCLUSION: Our results indicate a specific, task-related involvement of the STN in the cognitive activities. Cognitive processing in the STN is possibly processed via hyperdirect cortico-STN pathway. Certain effects of DBS surgery on cognitive performance could be explained by a direct effect on 'cognitive' parts of the STN.
- 590 __
- $a bohemika - dle Pubmed
- 650 02
- $a mapování mozku $7 D001931
- 650 02
- $a mozková kůra $x fyziologie $7 D002540
- 650 02
- $a kognice $x fyziologie $7 D003071
- 650 02
- $a elektrická stimulace $x metody $7 D004558
- 650 02
- $a elektroencefalografie $x metody $7 D004569
- 650 02
- $a exekutivní funkce $x fyziologie $7 D056344
- 650 02
- $a lidé $7 D006801
- 650 02
- $a nervové dráhy $x fyziologie $7 D009434
- 650 02
- $a Parkinsonova nemoc $x patofyziologie $x terapie $7 D010300
- 650 02
- $a nucleus subthalamicus $x fyziologie $7 D020531
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Baláž, Marek $7 xx0100990
- 700 1_
- $a Bočková, Martina $7 xx0121666
- 773 0_
- $t Parkinsonism & Related Disorders $p Parkinsonism Relat Disord $g Roč. 15, Suppl 3 (2009), s. S83-S86 $x 1353-8020 $w MED00006198
- 910 __
- $a ABA008 $b x $y 4 $z 0
- 990 __
- $a 20120319150909 $b ABA008
- 991 __
- $a 20160414081225 $b ABA008
- 999 __
- $a ok $b bmc $g 902350 $s 766032
- BAS __
- $a 3
- BMC __
- $a 2009 $b 15 $c Suppl 3 $d S83-S86 $i 1353-8020 $m Parkinsonism & related disorders $x MED00006198 $n Parkinsonism Relat Disord
- LZP __
- $a 2012-1Q10/x
