• Something wrong with this record ?

Lack of association between interleukin-18 –607 c/a gene polymorphism and pulmonary tuberculosis in Zahedan, Southeast Iran

Taheri M., Hashemi-Shahri S. M., Hamzehnejadi M., Naderi M., Moazeni-Roodi A., Bahari G., Hashemi M.

. 2012 ; 113 (1) : 16-22.

Language English Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc12013287

Interleukin-18 (IL-18) plays a critical role in immune response, contributing to the pathogenesis and pathophysiology of infectious diseases. Polymorphisms in the IL-18 genes are known to influence expression levels and may be associated with outcome of infections. The objective of this study was to determine whether the presence of IL-18 polymorphisms –607 A/C (rs1946518) was associated with tuberculosis disease. We investigated the functional polymorphism of IL-18 (rs1946518) in 174 patients with pulmonary tuberculosis (PTB) and 177 healthy subjects. Genotype analysis was done using tetra amplification refractory mutation system-PCR (T-ARMS-PCR). The allelic and genotypic frequencies of the IL-18 polymorphism did not differ significantly between PTB and the controls. Our finding suggests that IL-18 polymorphism (rs1946518) may not be a risk factor for susceptibility to tuberculosis in a sample of Iranian population. Further studies are required to validate our findings.

References provided by Crossref.org

Obsahuje 2 tabulky

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc12013287
003      
CZ-PrNML
005      
20120601125748.0
007      
ta
008      
120421s2012 xr o f 000 0eng||
009      
AR
024    7_
$a 10.14712/23362936.2015.33 $2 doi
040    __
$a ABA008 $d ABA008 $e AACR2 $b cze
041    0_
$a eng
044    __
$a xr
100    1_
$a Taheri, M. $u Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Genetics, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
245    10
$a Lack of association between interleukin-18 –607 c/a gene polymorphism and pulmonary tuberculosis in Zahedan, Southeast Iran / $c Taheri M., Hashemi-Shahri S. M., Hamzehnejadi M., Naderi M., Moazeni-Roodi A., Bahari G., Hashemi M.
500    __
$a Obsahuje 2 tabulky
504    __
$a Literatura $b 21
520    9_
$a Interleukin-18 (IL-18) plays a critical role in immune response, contributing to the pathogenesis and pathophysiology of infectious diseases. Polymorphisms in the IL-18 genes are known to influence expression levels and may be associated with outcome of infections. The objective of this study was to determine whether the presence of IL-18 polymorphisms –607 A/C (rs1946518) was associated with tuberculosis disease. We investigated the functional polymorphism of IL-18 (rs1946518) in 174 patients with pulmonary tuberculosis (PTB) and 177 healthy subjects. Genotype analysis was done using tetra amplification refractory mutation system-PCR (T-ARMS-PCR). The allelic and genotypic frequencies of the IL-18 polymorphism did not differ significantly between PTB and the controls. Our finding suggests that IL-18 polymorphism (rs1946518) may not be a risk factor for susceptibility to tuberculosis in a sample of Iranian population. Further studies are required to validate our findings.
650    02
$a ženské pohlaví $7 D005260
650    02
$a frekvence genu $7 D005787
650    02
$a genetická predispozice k nemoci $7 D020022
650    02
$a genotyp $7 D005838
650    02
$a lidé $7 D006801
650    02
$a interleukin-18 $x genetika $7 D020382
650    02
$a mužské pohlaví $7 D008297
650    02
$a lidé středního věku $7 D008875
650    02
$a jednonukleotidový polymorfismus $7 D020641
650    02
$a plicní tuberkulóza $x genetika $7 D014397
651    _2
$a Írán $7 D007492
700    1_
$a Hashemi-Shahri, S. Mohammad $u Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
700    1_
$a Hamzehnejadi, M. $u Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
700    1_
$a Naderi, M. $u Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
700    1_
$a Moazeni-Roodi, A. $u Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
700    1_
$a Bahari, G. $u Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
700    1_
$a Hashemi, M. $u Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
773    0_
$t Prague medical report $x 1214-6994 $g Roč. 113, č. 1 (2012), s. 16-22 $w MED00013414
856    41
$u https://pmr.lf1.cuni.cz/media/pdf/pmr_2012113010016.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 7 $c 1071 $y 2
990    __
$a 20120421064433 $b ABA008
991    __
$a 20120601125716 $b ABA008
999    __
$a ok $b bmc $g 906767 $s 770308
BAS    __
$a 3
BMC    __
$a 2012 $b 113 $c 1 $d 16-22 $i 1214-6994 $m Prague Medical Report $n Prague Med. Rep. $x MED00013414
LZP    __
$a 2012-18/vtme
Back

Find record

Citation metrics

Archiving options