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Biodegradation of tetrabromobisphenol A by oxidases in basidiomycetous fungi and estrogenic activity of the biotransformation products
B. Uhnáková, R. Ludwig, J. Pěknicová, L. Homolka, L. Lisá, M. Šulc, A. Petříčková, F. Elzeinová, H. Pelantová, D. Monti, V. Křen, D. Haltrich, L. Martínková
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Links
PubMed
21865031
DOI
10.1016/j.biortech.2011.07.036
Knihovny.cz E-resources
- MeSH
- Basidiomycota metabolism MeSH
- Biotransformation MeSH
- Estrogens metabolism MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Oxidoreductases metabolism MeSH
- Polybrominated Biphenyls metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Tetrabromobisphenol A (TBBPA) degradation was investigated using white rot fungi and their oxidative enzymes. Strains of the Trametes, Pleurotus, Bjerkandera and Dichomitus genera eliminated almost 1 mM TBBPA within 4 days. Laccase, whose role in TBBPA degradation was demonstrated in fungal cultures, was applied to TBBPA degradation alone and in combination with cellobiose dehydrogenase from Sclerotium rolfsii. Purified laccase from Trametes versicolor degraded approximately 2 mM TBBPA within 5 h, while the addition of cellobiose dehydrogenase increased the degradation rate to almost 2.5 mM within 3 h. Laccase was used to prepare TBBPA metabolites 2,6-dibromo-4-(2-hydroxypropane-2-yl) phenol (1), 2,6-dibromo-4-(2-methoxypropane-2-yl) phenol (2) and 1-(3,5-dibromo-4-hydroxyphen-1-yl)-2,2',6,6'-tetrabromo-4,4'-isopropylidene diphenol (3). As compounds 1 and 3 were identical to the TBBPA metabolites prepared by using rat and human liver fractions (Zalko et al., 2006), laccase can provide a simple means of preparing these metabolites for toxicity studies. Products 1 and 2 exhibited estrogenic effects, unlike TBBPA, but lower cell toxicity.
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