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Pregnancy-associated plasma protein A (PAPP-A) and soluble receptor for advanced glycation end products (sRAGE)--intra- and inter-individual variability in chronic hemodialysis patients
B. Míková, E. Jarolímková, H. Benáková, L. Dohnal, V. Tesař, T. Zima, M. Kalousová,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NS10043
MZ0
CEP Register
Digital library NLK
Full text - Article
Full text - Article
Source
NLK
Medline Complete (EBSCOhost)
from 1998-05-19 to 1 year ago
- MeSH
- Analysis of Variance MeSH
- Biomarkers blood MeSH
- Kidney Failure, Chronic blood complications therapy MeSH
- Renal Dialysis MeSH
- Cardiovascular Diseases blood etiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Leukocyte Count MeSH
- Prospective Studies MeSH
- Receptors, Immunologic blood MeSH
- Regression Analysis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Pregnancy-Associated Plasma Protein-A metabolism MeSH
- Transferrin metabolism MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Dialysis patients are at high risk of cardiovascular complications. Pregnancy-associated plasma protein A (PAPP-A) as well as sRAGE (soluble receptor for advanced glycation end products) are new biomarkers related to cardiovascular disease. The aim of our study was to describe their intra- and inter-individual variability. METHODS: The studied group consisted of 21 chronic hemodialysis patients. PAPP-A, sRAGE and selected routine parameters were measured monthly during a 1-year prospective study. RESULTS: Our results show high intra-individual variability of both PAPP-A and sRAGE. Both PAPP-A and sRAGE were closely linked to serum transferrin levels. Additionally, sRAGE was significantly associated with leukocyte count and haemoglobin. CONCLUSION: Our study demonstrates high intra-individual variability of PAPP-A and sRAGE in stable clinical status. This finding could be helpful for further evaluation of the significance of PAPP-A and sRAGE in chronic kidney disease.
References provided by Crossref.org
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