-
Je něco špatně v tomto záznamu ?
Study of urinary concentrations of mandelic acid in employees exposed to styrene
M. Poláková, Z. Krajcovicová, V. Melus, M. Stefkovicová, M. Sulcová,
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, tabulky
Digitální knihovna NLK
Zdroj
NLK
Free Medical Journals
od 2004
ProQuest Central
od 2009-03-01 do Před 6 měsíci
Medline Complete (EBSCOhost)
od 2006-03-01 do Před 6 měsíci
Nursing & Allied Health Database (ProQuest)
od 2009-03-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 2009-03-01 do Před 6 měsíci
Public Health Database (ProQuest)
od 2009-03-01 do Před 6 měsíci
ROAD: Directory of Open Access Scholarly Resources
od 1993
PubMed
23285526
DOI
10.21101/cejph.a3649
Knihovny.cz E-zdroje
- MeSH
- časové faktory MeSH
- kyseliny mandlové moč MeSH
- látky znečišťující vzduch v pracovním prostředí analýza metabolismus MeSH
- lidé MeSH
- monitorování životního prostředí metody MeSH
- plastické hmoty MeSH
- pracovní expozice analýza statistika a číselné údaje MeSH
- styren analýza metabolismus MeSH
- zaměstnání statistika a číselné údaje MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- tabulky MeSH
Mandelic acid (MA) is an important metabolite of styrene. In humans, measurement of its concentration in urine provides an important assessment of the overall level of styrene exposure in workers of the reinforced plastic manufacturing industry. The aim of our study was to investigate in these workers the relationship between MA concentration and styrene exposure time and intensity as well as its dependence on work occupation. The concentration of MA in the urine samples of 35 employees was analyzed with HPLC (high performance liquid chromatography). Out of 35 workers, 11 performed laminating, 11 milling and finalizing, 6 laying-up and spraying-up, and 7 worked in background support. Urinal samples were obtained twice a day over the course of three weeks, at the beginning and the end of the work shift. We found a significant increase in MA concentrations during a work shift in all tested days (Wilcoxon test p < 0.05). Employees working in elevated atmospheric concentrations of styrene (93.77-159.88 mg/m3) had significantly higher MA concentrations in urine compared to other groups at both the beginning and the end of the shift (Kruskal Wallis test p < 0.001) (p < 0.001). Only samples from laminating workers exceeded the biological limit of MA concentration (640 mg/L) at the end of the shift. Normalisation of MA concentration to body mass index (BMI, normal range: 21.7 +/- 3.2 kg/m2) refined differences within groups (Kruskal-Wallis analysis p < 0.001). The accumulation of MA at the end of the work shift for measured time period was not significant for the measured time period (Friedman analysis p > 0.11). Our results confirmed that MA is a sensitive metabolic marker of styrene exposure without cumulative effect. However, normalization of MA concentrations to BMI can improve the accuracy of styrene exposure estimates in certain groups of employees.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc13003361
- 003
- CZ-PrNML
- 005
- 20130205073919.0
- 007
- ta
- 008
- 130124s2012 xr d f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.21101/cejph.a3649 $2 doi
- 035 __
- $a (PubMed)23285526
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Poláková, Mária. $7 _AN071047 $u Regional Authority of Public Health, Trencin, Slovak Republic
- 245 10
- $a Study of urinary concentrations of mandelic acid in employees exposed to styrene / $c M. Poláková, Z. Krajcovicová, V. Melus, M. Stefkovicová, M. Sulcová,
- 520 9_
- $a Mandelic acid (MA) is an important metabolite of styrene. In humans, measurement of its concentration in urine provides an important assessment of the overall level of styrene exposure in workers of the reinforced plastic manufacturing industry. The aim of our study was to investigate in these workers the relationship between MA concentration and styrene exposure time and intensity as well as its dependence on work occupation. The concentration of MA in the urine samples of 35 employees was analyzed with HPLC (high performance liquid chromatography). Out of 35 workers, 11 performed laminating, 11 milling and finalizing, 6 laying-up and spraying-up, and 7 worked in background support. Urinal samples were obtained twice a day over the course of three weeks, at the beginning and the end of the work shift. We found a significant increase in MA concentrations during a work shift in all tested days (Wilcoxon test p < 0.05). Employees working in elevated atmospheric concentrations of styrene (93.77-159.88 mg/m3) had significantly higher MA concentrations in urine compared to other groups at both the beginning and the end of the shift (Kruskal Wallis test p < 0.001) (p < 0.001). Only samples from laminating workers exceeded the biological limit of MA concentration (640 mg/L) at the end of the shift. Normalisation of MA concentration to body mass index (BMI, normal range: 21.7 +/- 3.2 kg/m2) refined differences within groups (Kruskal-Wallis analysis p < 0.001). The accumulation of MA at the end of the work shift for measured time period was not significant for the measured time period (Friedman analysis p > 0.11). Our results confirmed that MA is a sensitive metabolic marker of styrene exposure without cumulative effect. However, normalization of MA concentrations to BMI can improve the accuracy of styrene exposure estimates in certain groups of employees.
- 650 _2
- $a látky znečišťující vzduch v pracovním prostředí $x analýza $x metabolismus $7 D000395
- 650 _2
- $a monitorování životního prostředí $x metody $7 D004784
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a kyseliny mandlové $x moč $7 D008333
- 650 _2
- $a pracovní expozice $x analýza $x statistika a číselné údaje $7 D016273
- 650 _2
- $a zaměstnání $x statistika a číselné údaje $7 D009790
- 650 _2
- $a plastické hmoty $7 D010969
- 650 _2
- $a styren $x analýza $x metabolismus $7 D020058
- 650 _2
- $a časové faktory $7 D013997
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a tabulky $7 D020501
- 700 1_
- $a Krajčovičová, Zdenka. $7 mzk2015889528 $u Department of Laboratory Medicine, Faculty of Healthcare, Alexander Dubček University of Trenčín, Slovak Republic
- 700 1_
- $a Meluš, Vladimír. $7 mzk2015889525 $u Department of Laboratory Medicine, Faculty of Healthcare, Alexander Dubček University of Trenčín, Slovak Republic
- 700 1_
- $a Štefkovičová, Mária $7 xx0143638 $u Regional Authority of Public Health, Trencin, Slovak Republic
- 700 1_
- $a Šulcová, Margaréta, $d 1940- $7 nlk20000090171 $u Department of Occupational Health, Faculty of Public Health, Slovak Medical University, Bratislava, Slovak Republic
- 773 0_
- $w MED00001083 $t Central European journal of public health $x 1210-7778 $g Roč. 20, č. 3 (2012), s. 226-232
- 910 __
- $a ABA008 $b B 1829 $c 562 $y 3 $z 0
- 990 __
- $a 20130124 $b ABA008
- 991 __
- $a 20130205074051 $b ABA008
- 999 __
- $a ok $b bmc $g 966932 $s 801554
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2012 $b 20 $c 3 $d 226-232 $i 1210-7778 $m Central European Journal of Public Health $n Cent. Eur. J. Public Health $x MED00001083
- LZP __
- $b NLK138 $a Pubmed-20130124
