-
Something wrong with this record ?
Cisatracurium vs. Rocuronium: A prospective, comparative, randomized study in adult patients under total intravenous anaesthesia
M. Adamus, R. Belohlavek, J. Koutna, M. Vujcikova, E. Janaskova
Language English Country Czech Republic
Document type Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
NLK
Directory of Open Access Journals
from 2001
Free Medical Journals
from 1998
ROAD: Directory of Open Access Scholarly Resources
from 2001
PubMed
17426802
DOI
10.5507/bp.2006.051
Knihovny.cz E-resources
- MeSH
- Androstanols administration & dosage MeSH
- Atracurium administration & dosage analogs & derivatives MeSH
- Anesthesia, Intravenous MeSH
- Middle Aged MeSH
- Humans MeSH
- Neuromuscular Nondepolarizing Agents administration & dosage MeSH
- Neuromuscular Blockade MeSH
- Neuromuscular Blocking Agents administration & dosage MeSH
- Anesthesia Recovery Period MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Comparative Study MeSH
Aims: To compare the pharmacodynamics of cisatracurium and rocuronium-induced neuromuscular block following single dose, allowing either spontaneous or neostigmine-accelerated complete recovery. METHODS: Following the ethics committee approval and informed consent, 120 patients scheduled for elective surgery under TIVA with tracheal intubation were randomized into 4 groups with different cisatracurium (CIS, 0.10 or 0.15 mg.kg(-1)) or rocuronium (ROC, 0.60 or 0.90 mg.kg(-1)) doses administered. For each patient, the onset time for 95 % depression of T1, clinical duration until 25 % recovery, recovery index (T1 from 25 to 75 %) and time from T1 25 % to TOF-ratio 0.9 were determined allowing either spontaneous or induced recovery. RESULTS: The onset times were 277 (SD 58), 220 (46), 91 (16) and 77 (16) s for the CIS 0.10, CIS 0.15, ROC 0.60 and ROC 0.90 groups (p < 0.05), respectively, with lower variability in both ROC groups (p < 0.05). The clinical durations were 42 (7), 52 (7), 35 (11) and 52 (12) min, respectively (p < 0.05 for lower doses). Recovery index was identical in all groups allowing either spontaneous recovery - 15.9 (1.8), 15.5 (1.7), 16.1 (3.7) and 16.1 (4.0) min, or following neostigmine administration - 4.4 (0.9), 4.5 (0.8), 4.3 (0.8) and 4.7 (0.7) min for respective groups. During spontaneous recovery, the variability of DUR25-TOF90 was twice as great for ROC than CIS groups (p < 0.05), while after neostigmine administration it was uniform in all groups. CONCLUSIONS: For equipotent doses, the onset times for CIS were approximately three times longer than for ROC. The average clinical duration for both relaxants ranged from 35 to 52 min with acceptable variability. Neostigmine administration accelerated the recovery and reduced its variability. When allowing for spontaneous recovery, less scatter was demonstrated for both CIS groups than for ROC ones.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc13003655
- 003
- CZ-PrNML
- 005
- 20130222120329.0
- 007
- ta
- 008
- 130128s2006 xr f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.5507/bp.2006.051 $2 doi
- 035 __
- $a (PubMed)17426802
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Adamus, Milan, $7 xx0041551 $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine, Palacky University, Olomouc $d 1957-
- 245 10
- $a Cisatracurium vs. Rocuronium: A prospective, comparative, randomized study in adult patients under total intravenous anaesthesia / $c M. Adamus, R. Belohlavek, J. Koutna, M. Vujcikova, E. Janaskova
- 520 9_
- $a Aims: To compare the pharmacodynamics of cisatracurium and rocuronium-induced neuromuscular block following single dose, allowing either spontaneous or neostigmine-accelerated complete recovery. METHODS: Following the ethics committee approval and informed consent, 120 patients scheduled for elective surgery under TIVA with tracheal intubation were randomized into 4 groups with different cisatracurium (CIS, 0.10 or 0.15 mg.kg(-1)) or rocuronium (ROC, 0.60 or 0.90 mg.kg(-1)) doses administered. For each patient, the onset time for 95 % depression of T1, clinical duration until 25 % recovery, recovery index (T1 from 25 to 75 %) and time from T1 25 % to TOF-ratio 0.9 were determined allowing either spontaneous or induced recovery. RESULTS: The onset times were 277 (SD 58), 220 (46), 91 (16) and 77 (16) s for the CIS 0.10, CIS 0.15, ROC 0.60 and ROC 0.90 groups (p < 0.05), respectively, with lower variability in both ROC groups (p < 0.05). The clinical durations were 42 (7), 52 (7), 35 (11) and 52 (12) min, respectively (p < 0.05 for lower doses). Recovery index was identical in all groups allowing either spontaneous recovery - 15.9 (1.8), 15.5 (1.7), 16.1 (3.7) and 16.1 (4.0) min, or following neostigmine administration - 4.4 (0.9), 4.5 (0.8), 4.3 (0.8) and 4.7 (0.7) min for respective groups. During spontaneous recovery, the variability of DUR25-TOF90 was twice as great for ROC than CIS groups (p < 0.05), while after neostigmine administration it was uniform in all groups. CONCLUSIONS: For equipotent doses, the onset times for CIS were approximately three times longer than for ROC. The average clinical duration for both relaxants ranged from 35 to 52 min with acceptable variability. Neostigmine administration accelerated the recovery and reduced its variability. When allowing for spontaneous recovery, less scatter was demonstrated for both CIS groups than for ROC ones.
- 650 _2
- $a androstanoly $x aplikace a dávkování $7 D000732
- 650 _2
- $a probouzení z anestezie $7 D000762
- 650 _2
- $a intravenózní anestezie $7 D000771
- 650 _2
- $a atrakurium $x aplikace a dávkování $x analogy a deriváty $7 D001279
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a nervosvalová blokáda $7 D019148
- 650 _2
- $a nervosvalové blokátory $x aplikace a dávkování $7 D009466
- 650 _2
- $a nedepolarizující myorelaxancia $x aplikace a dávkování $7 D003473
- 655 _2
- $a srovnávací studie $7 D003160
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a randomizované kontrolované studie $7 D016449
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Bělohlávek, Radim, $d 1971- $7 ola2002159140 $u Department of Computer Science, Palacky University, Olomouc
- 700 1_
- $a Koutná, Jiřina $7 xx0086647 $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine, Palacky University, Olomouc
- 700 1_
- $a Vujčíková, Mariana. $7 _AN071292 $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine, Palacky University, Olomouc
- 700 1_
- $a Janásková, Eva. $7 _AN071293 $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine, Palacky University, Olomouc
- 773 0_
- $w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic $x 1213-8118 $g Roč. 150, č. 2 (2006), s. 333-338
- 910 __
- $a ABA008 $b A 1502 $c sign $y 3 $z 0
- 990 __
- $a 20130128 $b ABA008
- 991 __
- $a 20130222120523 $b ABA008
- 999 __
- $a ok $b bmc $g 966311 $s 801850
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2006 $b 150 $c 2 $d 333-338 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
- LZP __
- $b NLK111 $a Pubmed-20130128
