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Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles
D. Fajkusova, M. Pesko, S. Keltosova, J. Guo, Z. Oktabec, M. Vejsova, P. Kollar, A. Coffey, J. Csollei, K. Kralova, J. Jampilek,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Antifungal Agents metabolism pharmacology MeSH
- Anti-Infective Agents chemical synthesis chemistry pharmacology MeSH
- Antineoplastic Agents chemical synthesis chemistry pharmacology MeSH
- Benzothiazoles chemical synthesis chemistry pharmacology MeSH
- Chloroplasts drug effects MeSH
- Herbicides chemical synthesis chemistry pharmacology MeSH
- Drug Screening Assays, Antitumor MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Cell Line, Tumor MeSH
- Spinacia oleracea MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
In this study, a series of N-substituted 2-aminobenzothiazoles was prepared according to a recently developed method. Twelve compounds were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the discussed compounds was also performed against fungal, bacterial and mycobacterial species. The biological activities of some compounds were comparable or higher than the standards phenoxymethylpenicillin or pyrazinamide. The most effective compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. For all compounds, the structure-activity relationships are discussed.
References provided by Crossref.org
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- $a Fajkusova, Dagmar $u Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 612 42 Brno, Czech Republic. adagmar@post.cz
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