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Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX

K. Kuca, K. Musilek, D. Jun, J. Karasova, O. Soukup, J. Pejchal, M. Hrabinova,

. 2013 ; 9 (5) : 689-693.

Language English Country Netherlands

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc14074794

Grant support
NT12062 MZ0 CEP Register

Nerve agents such as sarin, VX and tabun are organophosphorus compounds able to inhibit an enzyme acetylcholinesterase (AChE). AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication with these agents. None from the known AChE reactivators is able to reactivate AChE inhibited by all kinds of nerve agents. In this work, reactivation potency of seventeen structurally different AChE reactivators was tested in vitro and subsequently, relationship between their chemical structure and biological activity was outlined. VX was chosen as appropriate member of the nerve agent family.

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