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Mechanism of base excision with the hOGG1 DNA repair enzyme [Mechanism of base excision with the hOGG1 DNA repaeEnzyme]
Jakub Šebera, Lukáš Trantírek, Jiří Fukal, Yoshiyuki Tanaka, And Vladimír Sychrovský
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't
- Keywords
- human 8-oxoguanine glycosylase1 protein,
- MeSH
- Chemical Phenomena MeSH
- Deoxyguanosine chemistry MeSH
- DNA Glycosylases * chemistry MeSH
- DNA Repair Enzymes * chemistry MeSH
- Humans MeSH
- Models, Molecular MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substratespecific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.
Central European Institute of Technology Masaryk University Brno
Division of Pharmaceutical Chemistry Tohoku University Aobayama Aoba ku Sendai Japan
Mechanism of base excision with the hOGG1 DNA repaeEnzyme
Literatura
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