JavaScript NENÍ povolen !

Článek
Článek online

FT
Medvik - BMČ

Je něco špatně v tomto záznamu ?

A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer

M. Delahaye-Sourdeix, D. Anantharaman, MN. Timofeeva, V. Gaborieau, A. Chabrier, MP. Vallée, P. Lagiou, I. Holcátová, L. Richiardi, K. Kjaerheim, A. Agudo, X. Castellsagué, TV. Macfarlane, L. Barzan, C. Canova, NS. Thakker, DI. Conway, A. Znaor,...

Journal of the National Cancer Institute. 2015 ; 107 (5) : .

J Natl Cancer Inst
ISSN 1460-2105
Medvik
Zdroj

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural

Perzistentní odkaz https://www.medvik.cz/link/bmc15022779

Online Plný text

NLK Free Medical Journals od 1996 do Před 1 rokem
Open Access Digital Library od 1996-01-01

PubMed 25838448
DOI 10.1093/jnci/djv037
Knihovny.cz E-zdroje

MeSH
dospělí MeSH
genetická predispozice k nemoci MeSH
hodnocení rizik MeSH
jednonukleotidový polymorfismus * MeSH
kouření škodlivé účinky epidemiologie MeSH
lidé středního věku MeSH
lidé MeSH
logistické modely MeSH
nádory hlavy a krku genetika MeSH
odds ratio MeSH
pití alkoholu škodlivé účinky epidemiologie MeSH
protein BRCA2 genetika MeSH
rizikové faktory MeSH
senioři MeSH
spinocelulární karcinom genetika MeSH
studie případů a kontrol MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
Research Support, N.I.H., Extramural MeSH

Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. We analyzed the association between BRCA2 SNP rs11571833 and upper aerodigestive tract (UADT) cancer risk with multivariable unconditional logistic regression adjusted by sex and combinations of study and country for 5942 UADT squamous cell carcinoma case patients and 8086 control patients from nine different studies. All statistical tests were two-sided. rs11571833 was associated with UADT cancers (odds ratio = 2.53, 95% confidence interval = 1.89 to 3.38, P = 3x10(-10)) and was present in European, Latin American, and Indian populations but extremely rare in Japanese populations. The association appeared more apparent in smokers (current or former) compared with never smokers (P het = .026). A robust association between a truncating BRCA2 variant and UADT cancer risk suggests that treatment strategies orientated towards BRCA2 mutations may warrant further investigation in UADT tumors.

Citace poskytuje Crossref.org

000: 00000naa a2200000 a 4500

001: bmc15022779

003: CZ-PrNML

005: 20151019161404.0

007: ta

008: 150709s2015 xxu f 000 0|eng||

009: AR

024 7_: $a 10.1093/jnci/djv037 $2 doi

035 __: $a (PubMed)25838448

040 __: $a ABA008 $b cze $d ABA008 $e AACR2

041 0_: $a eng

044 __: $a xxu

100 1_: $a Delahaye-Sourdeix, Manon

245 12: $a A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer / $c M. Delahaye-Sourdeix, D. Anantharaman, MN. Timofeeva, V. Gaborieau, A. Chabrier, MP. Vallée, P. Lagiou, I. Holcátová, L. Richiardi, K. Kjaerheim, A. Agudo, X. Castellsagué, TV. Macfarlane, L. Barzan, C. Canova, NS. Thakker, DI. Conway, A. Znaor, CM. Healy, W. Ahrens, D. Zaridze, N. Szeszenia-Dabrowska, J. Lissowska, E. Fabianova, IN. Mates, V. Bencko, L. Foretova, V. Janout, MP. Curado, S. Koifman, A. Menezes, V. Wünsch-Filho, J. Eluf-Neto, P. Boffetta, L. Fernández Garrote, J. Polesel, M. Lener, E. Jaworowska, J. Lubiński, S. Boccia, T. Rajkumar, TA. Samant, MB. Mahimkar, K. Matsuo, S. Franceschi, G. Byrnes, P. Brennan, JD. McKay,

520 9_: $a Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. We analyzed the association between BRCA2 SNP rs11571833 and upper aerodigestive tract (UADT) cancer risk with multivariable unconditional logistic regression adjusted by sex and combinations of study and country for 5942 UADT squamous cell carcinoma case patients and 8086 control patients from nine different studies. All statistical tests were two-sided. rs11571833 was associated with UADT cancers (odds ratio = 2.53, 95% confidence interval = 1.89 to 3.38, P = 3x10(-10)) and was present in European, Latin American, and Indian populations but extremely rare in Japanese populations. The association appeared more apparent in smokers (current or former) compared with never smokers (P het = .026). A robust association between a truncating BRCA2 variant and UADT cancer risk suggests that treatment strategies orientated towards BRCA2 mutations may warrant further investigation in UADT tumors.

650 _2: $a dospělí $7 D000328

650 _2: $a senioři $7 D000368

650 _2: $a pití alkoholu $x škodlivé účinky $x epidemiologie $7 D000428

650 _2: $a protein BRCA2 $x genetika $7 D024682

650 _2: $a spinocelulární karcinom $x genetika $7 D002294

650 _2: $a studie případů a kontrol $7 D016022

650 _2: $a ženské pohlaví $7 D005260

650 _2: $a genetická predispozice k nemoci $7 D020022

650 _2: $a nádory hlavy a krku $x genetika $7 D006258

650 _2: $a lidé $7 D006801

650 _2: $a logistické modely $7 D016015

650 _2: $a mužské pohlaví $7 D008297

650 _2: $a lidé středního věku $7 D008875

650 _2: $a odds ratio $7 D016017

650 12: $a jednonukleotidový polymorfismus $7 D020641

650 _2: $a hodnocení rizik $7 D018570

650 _2: $a rizikové faktory $7 D012307

650 _2: $a kouření $x škodlivé účinky $x epidemiologie $7 D012907

655 _2: $a časopisecké články $7 D016428

655 _2: $a Research Support, N.I.H., Extramural $7 D052061

700 1_: $a Anantharaman, Devasena $7 gn_A_00005858

700 1_: $a Timofeeva, Maria N

700 1_: $a Gaborieau, Valérie

700 1_: $a Chabrier, Amélie

700 1_: $a Vallée, Maxime P

700 1_: $a Lagiou, Pagona

700 1_: $a Holcátová, Ivana

700 1_: $a Richiardi, Lorenzo

700 1_: $a Kjaerheim, Kristina

700 1_: $a Agudo, Antonio $7 gn_A_00002293

700 1_: $a Castellsagué, Xavier

700 1_: $a Macfarlane, Tatiana V

700 1_: $a Barzan, Luigi

700 1_: $a Canova, Cristina

700 1_: $a Thakker, Nalin S

700 1_: $a Conway, David I

700 1_: $a Znaor, Ariana

700 1_: $a Healy, Claire M

700 1_: $a Ahrens, Wolfgang $7 gn_A_00002543

700 1_: $a Zaridze, David

700 1_: $a Szeszenia-Dabrowska, Neonilia

700 1_: $a Lissowska, Jolanta

700 1_: $a Fabianova, Eleonora

700 1_: $a Mates, Ioan Nicolae

700 1_: $a Bencko, Vladimir

700 1_: $a Foretova, Lenka

700 1_: $a Janout, Vladimir

700 1_: $a Curado, Maria Paula

700 1_: $a Koifman, Sergio

700 1_: $a Menezes, Ana

700 1_: $a Wünsch-Filho, Victor

700 1_: $a Eluf-Neto, José

700 1_: $a Boffetta, Paolo

700 1_: $a Fernández Garrote, Leticia

700 1_: $a Polesel, Jerry

700 1_: $a Lener, Marcin

700 1_: $a Jaworowska, Ewa

700 1_: $a Lubiński, Jan

700 1_: $a Boccia, Stefania

700 1_: $a Rajkumar, Thangarajan

700 1_: $a Samant, Tanuja A

700 1_: $a Mahimkar, Manoj B

700 1_: $a Matsuo, Keitaro

700 1_: $a Franceschi, Silvia

700 1_: $a Byrnes, Graham

700 1_: $a Brennan, Paul

700 1_: $a McKay, James D

773 0_: $w MED00003002 $t Journal of the National Cancer Institute $x 1460-2105 $g Roč. 107, č. 5 (2015)

856 41: $u https://pubmed.ncbi.nlm.nih.gov/25838448 $y Pubmed

910 __: $a ABA008 $b sig $c sign $y a $z 0

990 __: $a 20150709 $b ABA008

991 __: $a 20151019161555 $b ABA008

999 __: $a ok $b bmc $g 1083118 $s 905772

BAS __: $a 3

BAS __: $a PreBMC

BMC __: $a 2015 $b 107 $c 5 $i 1460-2105 $m Journal of the National Cancer Institute $n J Natl Cancer Inst $x MED00003002

LZP __: $a Pubmed-20150709

Najít záznam

v PubMed

A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer

Najít záznam

Citační ukazatele

Možnosti archivace