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Outcome of invasive mechanical ventilation after pediatric allogeneic hematopoietic SCT: results from a prospective, multicenter registry
JP. van Gestel, MB. Bierings, S. Dauger, JH. Dalle, P. Pavlíček, P. Sedláček, LM. Monteiro, A. Lankester, CW. Bollen,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
NLK
Free Medical Journals
od 1997 do Před 1 rokem
Freely Accessible Science Journals
od 1997 do Před 1 rokem
ProQuest Central
od 1997-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Medline Complete (EBSCOhost)
od 1997-01-01 do 2015-11-30
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
PubMed
25068426
DOI
10.1038/bmt.2014.147
Knihovny.cz E-zdroje
- MeSH
- dítě MeSH
- homologní transplantace metody mortalita MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- příprava pacienta k transplantaci metody mortalita MeSH
- prognóza MeSH
- prospektivní studie MeSH
- rizikové faktory MeSH
- transplantace hematopoetických kmenových buněk metody mortalita MeSH
- umělé dýchání metody MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
Exact data on prognosis of children receiving invasive mechanical ventilation (IMV) after allogeneic hematopoietic SCT (HSCT) is lacking. We therefore started a prospective registry in four European university HSCT centers (Leiden, Paris, Prague and Utrecht) and their pediatric intensive care units (PICUs). The registry started in January 2009. In January 2013, the four centers together had treated a total of 83 admissions with IMV. The case fatality rate in these patients was 52%. Mortality 6 months after PICU discharge was 45%. There were significant differences between centers in the proportion of children who received IMV after HSCT (6-23%, P<0.01), in severity of disease on admission to PICU (predicted mortality 14-37%, P<0.01), in applying noninvasive ventilation before IMV (3-75% of admissions, P<0.01) and in the use of renal replacement therapy (RRT) (8-58% of admissions, P<0.01). Severe impairment in oxygenation, use of RRT and CMV viremia were independent predictors of mortality. Our study shows that mortality in children receiving IMV after HSCT remains high, but has clearly improved compared with older studies. Patient selection and treatment in PICU differed significantly between centers, which underscores the need to standardize and optimize the PICU admission criteria, ventilatory strategies and therapies applied in PICU.
Pediatric Intensive Care Unit Charles University Hospital Motol Prague Czech Republic
Pediatric Intensive Care Unit Leiden University Medical Center Leiden The Netherlands
Citace poskytuje Crossref.org
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