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Highly efficient mesenchymal stem cell proliferation on poly-ε-caprolactone nanofibers with embedded magnetic nanoparticles

J. Daňková, M. Buzgo, J. Vejpravová, S. Kubíčková, V. Sovková, L. Vysloužilová, A. Mantlíková, A. Nečas, E. Amler,

. 2015 ; 10 (-) : 7307-7317. [pub] 20151207

Jazyk angličtina Země Nový Zéland

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16027832

Grantová podpora
NT12156 MZ0 CEP - Centrální evidence projektů

In this study, we have developed a combined approach to accelerate the proliferation of mesenchymal stem cells (MSCs) in vitro, using a new nanofibrous scaffold made by needleless electrospinning from a mixture of poly-ε-caprolactone and magnetic particles. The biological characteristics of porcine MSCs were investigated while cultured in vitro on composite scaffold enriched with magnetic nanoparticles. Our data indicate that due to the synergic effect of the poly-ε-caprolactone nanofibers and magnetic particles, cellular adhesion and proliferation of MSCs is enhanced and osteogenic differentiation is supported. The cellular and physical attributes make this new scaffold very promising for the acceleration of efficient MSC proliferation and regeneration of hard tissues.

Citace poskytuje Crossref.org

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$a Vejpravová, Jana $u Department of Magnetic Nanosystems, Institute of Physics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
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