-
Something wrong with this record ?
Acetaldehyde at clinically relevant concentrations inhibits inward rectifier potassium current I(K1) in rat ventricular myocytes
M. Bébarová, P. Matejovič, M. Šimurdová, J. Šimurda
Language English Country Czech Republic
Document type Journal Article
Grant support
NT14301
MZ0
CEP Register
NLK
Directory of Open Access Journals
from 1991
Free Medical Journals
from 1998
ProQuest Central
from 2005-01-01
Medline Complete (EBSCOhost)
from 2006-01-01
Nursing & Allied Health Database (ProQuest)
from 2005-01-01
Health & Medicine (ProQuest)
from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1998
- MeSH
- Acetaldehyde pharmacology MeSH
- Potassium Channels, Inwardly Rectifying antagonists & inhibitors metabolism MeSH
- Myocytes, Cardiac drug effects metabolism MeSH
- Patch-Clamp Techniques MeSH
- Alcoholic Intoxication metabolism MeSH
- Rats, Wistar MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Considering the effects of alcohol on cardiac electrical behavior as well as the important role of the inward rectifier potassium current I(K1) in arrhythmogenesis, this study was aimed at the effect of acetaldehyde, the primary metabolite of ethanol, on I(K1) in rat ventricular myocytes. Acetaldehyde induced a reversible inhibition of I(K1) with IC(50) = 53.7+/-7.7 microM at -110 mV; a significant inhibition was documented even at clinically-relevant concentrations (at 3 microM by 13.1+/-3.0 %). The inhibition was voltage-independent at physiological voltages above -90 mV. The I(K1) changes under acetaldehyde may contribute to alcohol-induced alterations of cardiac electrophysiology, especially in individuals with a genetic defect of aldehyde dehydrogenase where the acetaldehyde level may be elevated.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc16031119
- 003
- CZ-PrNML
- 005
- 20190926105416.0
- 007
- ta
- 008
- 161101s2015 xr d f 000 0|ENG||
- 009
- AR
- 024 7_
- $a 10.33549/physiolres.932985 $2 doi
- 035 __
- $a (PubMed)26047378
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a ENG
- 044 __
- $a xr
- 100 1_
- $a Bébarová, Markéta, $d 1976- $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic $7 xx0037780
- 245 10
- $a Acetaldehyde at clinically relevant concentrations inhibits inward rectifier potassium current I(K1) in rat ventricular myocytes / $c M. Bébarová, P. Matejovič, M. Šimurdová, J. Šimurda
- 520 9_
- $a Considering the effects of alcohol on cardiac electrical behavior as well as the important role of the inward rectifier potassium current I(K1) in arrhythmogenesis, this study was aimed at the effect of acetaldehyde, the primary metabolite of ethanol, on I(K1) in rat ventricular myocytes. Acetaldehyde induced a reversible inhibition of I(K1) with IC(50) = 53.7+/-7.7 microM at -110 mV; a significant inhibition was documented even at clinically-relevant concentrations (at 3 microM by 13.1+/-3.0 %). The inhibition was voltage-independent at physiological voltages above -90 mV. The I(K1) changes under acetaldehyde may contribute to alcohol-induced alterations of cardiac electrophysiology, especially in individuals with a genetic defect of aldehyde dehydrogenase where the acetaldehyde level may be elevated.
- 650 _2
- $a acetaldehyd $x farmakologie $7 D000079
- 650 _2
- $a otrava alkoholem $x metabolismus $7 D000435
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a kardiomyocyty $x účinky léků $x metabolismus $7 D032383
- 650 _2
- $a metoda terčíkového zámku $7 D018408
- 650 _2
- $a draslíkové kanály dovnitř usměrňující $x antagonisté a inhibitory $x metabolismus $7 D024661
- 650 _2
- $a potkani Wistar $7 D017208
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Matejovič, Peter $7 _BN001184 $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
- 700 1_
- $a Šimurdová, Milena $7 xx0117620 $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
- 700 1_
- $a Šimurda, Jiří, $d 1937- $7 jn20000402828 $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
- 773 0_
- $w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 64, č. 6 (2015), s. 939-943
- 856 41
- $u http://www.biomed.cas.cz/physiolres/ $y domovská stránka časopisu
- 910 __
- $a ABA008 $b A 4120 $c 266 $y 4 $z 0
- 990 __
- $a 20161101 $b ABA008
- 991 __
- $a 20190926105816 $b ABA008
- 999 __
- $a ok $b bmc $g 1172206 $s 955777
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 64 $c 6 $d 939-943 $e 2015Jun05 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
- GRA __
- $a NT14301 $p MZ0
- LZP __
- $b NLK118 $a Pubmed-20161101
