-
Je něco špatně v tomto záznamu ?
Phototoxic potential of silymarin and its bioactive components
A. Rajnochová Svobodová, B. Zálešák, D. Biedermann, J. Ulrichová, J. Vostálová,
Jazyk angličtina Země Švýcarsko
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
- MeSH
- buňky 3T3 MeSH
- kultivované buňky MeSH
- lidé MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- silymarin toxicita MeSH
- ultrafialové záření * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
Silymarin, a standardized extract of the seeds of the milk thistle (Silybum marianum) and its major component, silybin, is now used as an active component in a broad spectrum of dietary supplements, cosmetics and dermatological preparations. However, despite its use in skin products, there are no published data to exclude its phototoxic potential. The primary purpose of this study was to examine the phototoxicity of silymarin and its flavonolignans, silybin, isosilybin, silychristin, silydianin and 2,3-dehydrosilybin by validated 3T3 NRU assay. Further, we compared the validated biological system Balc/c 3T3 cell line with other cell models, particularly normal human dermal fibroblasts (NHDF), normal human epidermal keratinocytes (NHEK) and the human keratinocyte cell line (HaCaT). The results showed that silymarin and the flavonolignans silybin, isosilybin, silychristin and silydianin had no phototoxicity towards any of the cells used. In contrast, 2,3-dehydrosilybin was identified as a compound with phototoxic potential. Further study is needed to evaluate the health risks associated with 2,3-dehydrosilybin use in skin preparations.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17000517
- 003
- CZ-PrNML
- 005
- 20171211150257.0
- 007
- ta
- 008
- 170103s2016 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.jphotobiol.2016.01.011 $2 doi
- 024 7_
- $a 10.1016/j.jphotobiol.2016.01.011 $2 doi
- 035 __
- $a (PubMed)26851710
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Rajnochová Svobodová, Alena $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 779 00 Olomouc, Czech Republic.
- 245 10
- $a Phototoxic potential of silymarin and its bioactive components / $c A. Rajnochová Svobodová, B. Zálešák, D. Biedermann, J. Ulrichová, J. Vostálová,
- 520 9_
- $a Silymarin, a standardized extract of the seeds of the milk thistle (Silybum marianum) and its major component, silybin, is now used as an active component in a broad spectrum of dietary supplements, cosmetics and dermatological preparations. However, despite its use in skin products, there are no published data to exclude its phototoxic potential. The primary purpose of this study was to examine the phototoxicity of silymarin and its flavonolignans, silybin, isosilybin, silychristin, silydianin and 2,3-dehydrosilybin by validated 3T3 NRU assay. Further, we compared the validated biological system Balc/c 3T3 cell line with other cell models, particularly normal human dermal fibroblasts (NHDF), normal human epidermal keratinocytes (NHEK) and the human keratinocyte cell line (HaCaT). The results showed that silymarin and the flavonolignans silybin, isosilybin, silychristin and silydianin had no phototoxicity towards any of the cells used. In contrast, 2,3-dehydrosilybin was identified as a compound with phototoxic potential. Further study is needed to evaluate the health risks associated with 2,3-dehydrosilybin use in skin preparations.
- 650 _2
- $a buňky 3T3 $7 D016475
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a kultivované buňky $7 D002478
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a myši inbrední BALB C $7 D008807
- 650 _2
- $a silymarin $x toxicita $7 D012838
- 650 12
- $a ultrafialové záření $7 D014466
- 655 _2
- $a srovnávací studie $7 D003160
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Zálešák, Bohumil, $d 1961- $u Department of Plastic and Aesthetic Surgery, University Hospital Olomouc, I. P. Pavlova 6, 779 00 Olomouc, Czech Republic. $7 xx0060519
- 700 1_
- $a Biedermann, David $u Institute of Microbiology, Laboratory of Biotransformation, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague, Czech Republic.
- 700 1_
- $a Ulrichová, Jitka $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 779 00 Olomouc, Czech Republic.
- 700 1_
- $a Vostálová, Jitka $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 779 00 Olomouc, Czech Republic. Electronic address: j.psotova@email.cz.
- 773 0_
- $w MED00006656 $t Journal of photochemistry and photobiology. B, Biology $x 1873-2682 $g Roč. 156, č. - (2016), s. 61-8
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26851710 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20170103 $b ABA008
- 991 __
- $a 20171211150443 $b ABA008
- 999 __
- $a ok $b bmc $g 1179657 $s 961084
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2016 $b 156 $c - $d 61-8 $e 20160126 $i 1873-2682 $m Journal of photochemistry and photobiology. B, Biology $n J Photochem Photobiol B $x MED00006656
- LZP __
- $a Pubmed-20170103
