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Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases
K. Mellgren, A. Attarbaschi, O. Abla, S. Alexander, S. Bomken, E. Bubanska, A. Chiang, M. Csóka, A. Fedorova, E. Kabickova, L. Kapuscinska-Kemblowska, R. Kobayashi, Z. Krenova, F. Meyer-Wentrup, N. Miakova, M. Pillon, G. Plat, A. Uyttebroeck, D....
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, multicentrická studie
NLK
ProQuest Central
od 1997-03-01
Medline Complete (EBSCOhost)
od 2000-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 1997-03-01
Health & Medicine (ProQuest)
od 1997-03-01
Springer Nature OA/Free Journals
od 1955-03-01
- MeSH
- dítě MeSH
- hodnocení výsledků zdravotní péče metody MeSH
- indukce remise MeSH
- kojenec MeSH
- kombinovaná terapie MeSH
- lidé MeSH
- mezinárodní spolupráce MeSH
- mladiství MeSH
- mladý dospělý MeSH
- periferní T-buněčný lymfom terapie MeSH
- předškolní dítě MeSH
- přežití bez známek nemoci MeSH
- protokoly protinádorové kombinované chemoterapie terapeutické užití MeSH
- retrospektivní studie MeSH
- transplantace hematopoetických kmenových buněk metody statistika a číselné údaje MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
Peripheral T cell lymphomas (PTCL) are rare in children and adolescents, and data about outcome and treatment results are scarce. The present study is a joint, international, retrospective analysis of 143 reported cases of non-anaplastic PTCL in patients <19 years of age, with a focus on treatment and outcome features. One hundred forty-three patients, between 0.3 and 18.7 years old, diagnosed between 2000 and 2015 were included in the study. PTCL not otherwise specified was the largest subgroup, followed by extranodal NK/T cell lymphoma, hepatosplenic T cell lymphoma (HS TCL), and subcutaneous panniculitis-like T cell lymphoma (SP TCL). Probability of overall survival (pOS) at 5 years for the whole group was 0.56 ± 0.05, and probability of event-free survival was (pEFS) 0.45 ± 0.05. Patients with SP TCL had a good outcome with 5-year pOS of 0.78 ± 0.1 while patients with HS TCL were reported with 5-year pOS of only 0.13 ± 0.12. Twenty-five percent of the patients were reported to have a pre-existing condition, and this group had a dismal outcome with 5-year pOS of 0.29 ± 0.09. The distribution of non-anaplastic PTCL subtypes in pediatric and adolescent patients differs from what is reported in adult patients. Overall outcome depends on the subtype with some doing better than others. Pre-existing conditions are frequent and associated with poor outcomes. There is a clear need for subtype-based treatment recommendations for children and adolescents with PTCL.
Belarusian Research Center for Pediatric Oncology Hematology and Immunology Minsk Belarus
Clinic of Paediatrics Haemathology and Oncology Medical University of Gdansk Gdansk Poland
Department of Pediatric Oncology Hôpital des Enfants Toulouse France
Department of Pediatrics Sapporo Hokuyu Hospital Sapporo Japan
Pediatric Hematology and Oncology Semmelweis University Budapest Hungary
Pediatric Hematology and Oncology University Hospitals Leuven Leuven Belgium
Pediatric Hematology and Oncology University of Padova Padova Italy
Pediatric Oncology and Hematology University Hospital Brno Czech Republic
Princess Maxima Center for Pediatric Oncology Utrecht The Netherlands
Citace poskytuje Crossref.org
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