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Tick-host conflict: immunoglobulin E antibodies to tick proteins in patients with anaphylaxis to tick bite
L. Mateos-Hernández, M. Villar, A. Moral, CG. Rodríguez, TA. Arias, V. de la Osa, FF. Brito, IG. Fernández de Mera, P. Alberdi, F. Ruiz-Fons, A. Cabezas-Cruz, A. Estrada-Peña, J. de la Fuente,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
PubMed Central od 2010
Europe PubMed Central od 2010
Open Access Digital Library od 2010-01-01
Odkazy
PubMed
28423486
DOI
10.18632/oncotarget.15243
Knihovny.cz E-zdroje
- MeSH
- 2D gelová elektroforéza MeSH
- anafylaxe imunologie MeSH
- antigeny imunologie MeSH
- imunoglobulin E imunologie MeSH
- klíšťata imunologie MeSH
- kousnutí klíštětem komplikace imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- proteiny členovců imunologie MeSH
- proteomika MeSH
- western blotting MeSH
- zvířata MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Tick-borne infectious diseases and allergies are a growing problem worldwide. Tick bite allergy has been associated with the direct effect of immunoglobulin E (IgE) response to tick salivary antigens, or secondary to the induction of allergy to red meat consumption through IgE antibodies against the carbohydrate α-Gal (Gal α 1-3Gal β 1-(3)4GlcNAc-R). However, despite the growing burden of this pathology, the proteins associated with anaphylaxis to tick bite have not been characterized. To address this question, a comparative proteomics approach was used to characterize tick proteins producing an IgE antibody response in a healthy individual with record of tick bites, which had not resulted in any allergic reactions, and two patients with anaphylactic reactions to Rhipicephalus bursa or Hyalomma marginatum tick bites. Both patients and the healthy individual were red meat tolerant. The results supported a patient-specific IgE antibody response to tick species responsible for the anaphylaxis to tick bite. Both patients and the healthy individual serologically recognized tick proteins with and without α-Gal modifications, with proteins differentially recognized by patients but not control sera. These proteins could be used as potential antigens for diagnostics, treatment and prevention of tick bite-induced allergies.
Allergy Section General University Hospital of Ciudad Real Ciudad Real Spain
Department of Allergy Hospital Virgen del Valle Toledo Spain
SaBio Instituto de Investigación de Recursos Cinegéticos IREC CSIC UCLM JCCM Ciudad Real Spain
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- $a Tick-borne infectious diseases and allergies are a growing problem worldwide. Tick bite allergy has been associated with the direct effect of immunoglobulin E (IgE) response to tick salivary antigens, or secondary to the induction of allergy to red meat consumption through IgE antibodies against the carbohydrate α-Gal (Gal α 1-3Gal β 1-(3)4GlcNAc-R). However, despite the growing burden of this pathology, the proteins associated with anaphylaxis to tick bite have not been characterized. To address this question, a comparative proteomics approach was used to characterize tick proteins producing an IgE antibody response in a healthy individual with record of tick bites, which had not resulted in any allergic reactions, and two patients with anaphylactic reactions to Rhipicephalus bursa or Hyalomma marginatum tick bites. Both patients and the healthy individual were red meat tolerant. The results supported a patient-specific IgE antibody response to tick species responsible for the anaphylaxis to tick bite. Both patients and the healthy individual serologically recognized tick proteins with and without α-Gal modifications, with proteins differentially recognized by patients but not control sera. These proteins could be used as potential antigens for diagnostics, treatment and prevention of tick bite-induced allergies.
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