Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate

J. Kudlacek, J. Chvojka, A. Posusta, L. Kovacova, SB. Hong, S. Weiss, K. Volna, P. Marusic, J. Otahal, P. Jiruska,

. 2017 ; 8 (-) : 687. [pub] 20171221

Language English Country Switzerland

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc18010099

Grant support
NV15-29835A MZ0 CEP Register
NV17-28427A MZ0 CEP Register

Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery. Their practical clinical utilization is curtailed by the inability to discriminate them from physiological oscillations due to frequency overlap. Although it is well documented that pathological HFOs are suppressed by antiepileptic drugs (AEDs), the effect of AEDs on normal HFOs is not well known. In this experimental study, we have explored whether physiological HFOs (sharp-wave ripples) of hippocampal origin respond to AED treatment. The results show that application of a single dose of levetiracetam or lacosamide does not reduce the rate of sharp-wave ripples. In addition, it seems that these new generation drugs do not negatively affect the cellular and network mechanisms involved in sharp-wave ripple generation, which may provide a plausible explanation for the absence of significant negative effects on cognitive functions of these drugs, particularly on memory.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18010099
003      
CZ-PrNML
005      
20201101111104.0
007      
ta
008      
180404s2017 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fneur.2017.00687 $2 doi
035    __
$a (PubMed)29312120
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Kudlacek, Jan $u Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia. Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czechia.
245    10
$a Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate / $c J. Kudlacek, J. Chvojka, A. Posusta, L. Kovacova, SB. Hong, S. Weiss, K. Volna, P. Marusic, J. Otahal, P. Jiruska,
520    9_
$a Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery. Their practical clinical utilization is curtailed by the inability to discriminate them from physiological oscillations due to frequency overlap. Although it is well documented that pathological HFOs are suppressed by antiepileptic drugs (AEDs), the effect of AEDs on normal HFOs is not well known. In this experimental study, we have explored whether physiological HFOs (sharp-wave ripples) of hippocampal origin respond to AED treatment. The results show that application of a single dose of levetiracetam or lacosamide does not reduce the rate of sharp-wave ripples. In addition, it seems that these new generation drugs do not negatively affect the cellular and network mechanisms involved in sharp-wave ripple generation, which may provide a plausible explanation for the absence of significant negative effects on cognitive functions of these drugs, particularly on memory.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Chvojka, Jan $u Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia. Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czechia.
700    1_
$a Posusta, Antonin $u Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia.
700    1_
$a Kovacova, Lubica $u Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia.
700    1_
$a Hong, Seung Bong $u Department of Neurology, Samsung Medical Center, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University School of Medicine, Seoul, South Korea. Samsung Biomedical Research Institute, Seoul, South Korea.
700    1_
$a Weiss, Shennan $u Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
700    1_
$a Volna, Kamila $u Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
700    1_
$a Marusic, Petr $u Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
700    1_
$a Otahal, Jakub $u Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia.
700    1_
$a Jiruska, Premysl $u Department of Developmental Epileptology, Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia.
773    0_
$w MED00174552 $t Frontiers in neurology $x 1664-2295 $g Roč. 8, č. - (2017), s. 687
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29312120 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180404 $b ABA008
991    __
$a 20201101111104 $b ABA008
999    __
$a ind $b bmc $g 1287584 $s 1006911
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 8 $c - $d 687 $e 20171221 $i 1664-2295 $m Frontiers in neurology $n Front. neurol. $x MED00174552
GRA    __
$a NV15-29835A $p MZ0
GRA    __
$a NV17-28427A $p MZ0
LZP    __
$a Pubmed-20180404

Find record

Citation metrics

Archiving options