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Phylogenetic analysis of Puumala virus strains from Central Europe highlights the need for a full-genome perspective on hantavirus evolution
R. Szabó, L. Radosa, M. Ličková, M. Sláviková, M. Heroldová, M. Stanko, M. Pejčoch, A. Osterberg, L. Laenen, S. Schex, RG. Ulrich, S. Essbauer, P. Maes, B. Klempa,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-02-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 1997-01-01 do Před 1 rokem
- MeSH
- Arvicolinae virologie MeSH
- fylogeneze MeSH
- genotyp MeSH
- hantavirové infekce virologie MeSH
- Hantavirus genetika MeSH
- lidé MeSH
- molekulární evoluce MeSH
- RNA virová genetika MeSH
- virus Puumala genetika MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- Evropa MeSH
- Německo MeSH
- Slovenská republika MeSH
Puumala virus (PUUV), carried by bank voles (Myodes glareolus), is the medically most important hantavirus in Central and Western Europe. In this study, a total of 523 bank voles (408 from Germany, 72 from Slovakia, and 43 from Czech Republic) collected between the years 2007-2012 were analyzed for the presence of hantavirus RNA. Partial PUUV genome segment sequences were obtained from 51 voles. Phylogenetic analyses of all three genome segments showed that the newfound strains cluster with other Central and Western European PUUV strains. The new sequences from Šumava (Bohemian Forest), Czech Republic, are most closely related to the strains from the neighboring Bavarian Forest, a known hantavirus disease outbreak region. Interestingly, the Slovak strains clustered with the sequences from Bohemian and Bavarian Forests only in the M but not S segment analyses. This well-supported topological incongruence suggests a segment reassortment event or, as we analyzed only partial sequences, homologous recombination. Our data highlight the necessity of sequencing all three hantavirus genome segments and of a broader bank vole screening not only in recognized endemic foci but also in regions with no reported human hantavirus disease cases.
Biomedical Research Center Institute of Virology Slovak Academy of Sciences Bratislava Slovakia
Department of Forest Ecology Mendel University in Brno Brno Czech Republic
Department of Virology and Rickettsiology Bundeswehr Institute of Microbiology Munich Germany
Institute of Parasitology Slovak Academy of Sciences Košice Slovakia
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- $a Szabó, Róbert $u Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia. Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia. Department of Biomedical Sciences, University of Cagliari, Monserrato, CA, Italy.
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- $a Puumala virus (PUUV), carried by bank voles (Myodes glareolus), is the medically most important hantavirus in Central and Western Europe. In this study, a total of 523 bank voles (408 from Germany, 72 from Slovakia, and 43 from Czech Republic) collected between the years 2007-2012 were analyzed for the presence of hantavirus RNA. Partial PUUV genome segment sequences were obtained from 51 voles. Phylogenetic analyses of all three genome segments showed that the newfound strains cluster with other Central and Western European PUUV strains. The new sequences from Šumava (Bohemian Forest), Czech Republic, are most closely related to the strains from the neighboring Bavarian Forest, a known hantavirus disease outbreak region. Interestingly, the Slovak strains clustered with the sequences from Bohemian and Bavarian Forests only in the M but not S segment analyses. This well-supported topological incongruence suggests a segment reassortment event or, as we analyzed only partial sequences, homologous recombination. Our data highlight the necessity of sequencing all three hantavirus genome segments and of a broader bank vole screening not only in recognized endemic foci but also in regions with no reported human hantavirus disease cases.
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