A 17-week-old crossbred finishing pig was presented for lameness of approximately one week. Clinical evaluation, including ophthalmologic examination, revealed ataxia, partial flaccid paresis of the pelvic limbs, skin lesions at feet and claws, and severely reduced vision/blindness. Both eyes had multiple persistent pupillary membranes (iris-to-iris and iris-to-lens) and hypermature cataracts. Histopathological examination of the eyes revealed microphthalmia, microphakia with cataract formation, myovascularised membrane in the vitreous, retinal detachment, and retinal dysplasia. Microscopic examination of tissues collected postmortem demonstrated nonsuppurative polioencephalomyelitis with the most prominent inflammatory lesions in the lumbar spinal cord. Subsequently, presumed Teschen/Talfan disease was confirmed by porcine teschovirus identification in the spinal cord using the reverse transcription-polymerase chain reaction (RT-PCR). To the authors' knowledge, this is the first case report describing in detail histopathological changes in the porcine congenital microphthalmic syndrome.

Department for Farm Animals Division of Swine Medicine Vetsuisse Faculty University of Zürich Winterthurerstrasse 270 8057 Zürich Switzerland

Equine Department Section of Ophthalmology Vetsuisse Faculty University of Zurich Winterthurerstrasse 260 8057 Zürich Switzerland

Institute of Veterinary Pathology Vetsuisse Faculty University of Zürich Winterthurerstrasse 270 8057 Zürich Switzerland

Veterinary Research Institute Hudcova 296 70 621 00 Brno Czech Republic

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