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CNS progression during vinblastine or targeted therapies for high-risk relapsed ALK-positive anaplastic large cell lymphoma: A case series

S. Ruf, H. Hebart, LL. Hjalgrim, E. Kabickova, P. Lang, D. Steinbach, GC. Schwabe, W. Woessmann,

. 2018 ; 65 (6) : e27003. [pub] 20180307

Language English Country United States

Document type Case Reports, Journal Article

Persistent link   https://www.medvik.cz/link/bmc19028531

Vinblastine and targeted therapies induce remissions in patients with relapsed or progressive anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL). Central nervous system (CNS) prophylaxis often is not included during re-induction in CNS-negative relapse patients. We report on five patients with progressive or early relapsed ALK-positive ALCL who developed CNS progression during re-induction with vinblastine, crizotinib, or brentuximab vedotin given for bridging to allogeneic blood stem cell transplantation. These observations suggest that CNS prophylaxis should be considered in ALCL patients suffering progression during initial therapy who receive re-induction using agents with limited CNS penetration.

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$a Hebart, Holger $u Department of Internal Medicine, Stauferklinikum Schwaebisch Gmuend, Mutlangen, Germany.
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$a Hjalgrim, Lisa Lyngsie $u The Child and Youth Clinic, Department of Pediatric Hematology and Oncology, University Hospital Copenhagen, Copenhagen, Denmark.
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$a Kabickova, Edita $u Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic.
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$a Lang, Peter $u Department of Pediatric Hematology and Oncology, Eberhard Karls University Tuebingen, Tuebingen, Germany.
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$a Steinbach, Daniel $u Department of Pediatric Hematology and Oncology, University Hospital Ulm, Ulm, Germany.
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