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Nasal nitric oxide in healthy adults - reference values and affecting factors
M. Antosova, D. Mokra, I. Tonhajzerova, P. Mikolka, P. Kosutova, M. Mestanik, L. Pepucha, J. Plevkova, T. Buday, V. Calkovsky, A. Bencova
Language English Country Czech Republic
Document type Journal Article
E-resources NLK Online Full text
Directory of Open Access Journals from 1991Free Medical Journals from 1998
ProQuest Central from 2005-01-01
Medline Complete (EBSCOhost) from 2006-01-01
Nursing & Allied Health Database (ProQuest) from 2005-01-01
Health & Medicine (ProQuest) from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources from 1998
Links
PubMed
28937239
DOI
10.33549/physiolres.933680
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Nasal Mucosa chemistry metabolism MeSH
- Nitric Oxide analysis metabolism MeSH
- Reference Values MeSH
- Respiratory Function Tests methods MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Nitric oxide (NO) is an important endogenous mediator with significant role in the respiratory system. Many endogenous and exogenous factors influence the synthesis of NO and its level is significantly changed during the inflammation. Analysis of nasal nitric oxide (nNO) is not validated so far as the diagnostic method. There is a lack of reference values with possible identification of factors modulating the nNO levels. In healthy adult volunteers (n=141) we studied nasal NO values by NIOX MINO® (Aerocrine, Sweden) according to the recommendations of the ATS & ERS. Gender, age, height, body weight, waist-to-hip ratio, FEV1/FVC, PEF and numbers of leukocytes, eosinophils, basophils and monocytes were studied as potential variables influencing the levels of nNO. The complexity of the results allowed us to create a homogenous group for nasal NO monitoring and these data can be used further as the reference data for given variables. Because of significant correlation between nNO and exhaled NO, our results support the "one airway - one disease" concept. Reference values of nasal NO and emphasis of the individual parameters of tested young healthy population may serve as a starting point in the non-invasive monitoring of the upper airway inflammation.
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- $a Antošová, M. $7 _AN070563 $u Biomedical Center Martin, Division of Respirology Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
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