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Polyglobalide-Based Porous Networks Containing Poly(ethylene glycol) Structures Prepared by Photoinitiated Thiol-Ene Coupling
CL. Savin, C. Peptu, Z. Kroneková, M. Sedlačík, M. Mrlik, V. Sasinková, CA. Peptu, M. Popa, J. Mosnáček,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- 3T3 Cells MeSH
- Esters chemistry MeSH
- Hydrogels adverse effects chemical synthesis chemistry MeSH
- Lactones chemistry MeSH
- Mice MeSH
- Polyethylene Glycols chemistry MeSH
- Sulfur Compounds chemistry MeSH
- Ultraviolet Rays MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The high interest in polymers from natural resources prompted us to investigate the use of enzymatically synthesized polyglobalide (PGL) in the preparation of polymer networks with potential applications as biomaterials for drug delivery devices. Polymer networks were obtained under mild conditions by photoinitiated thiol-ene coupling between PGL and a poly(ethylene glycol- co-thiomalate) (PEG-SH) copolymer obtained by polycondensation. The obtained polymer networks were thoroughly characterized by Raman spectroscopy, scanning electron microscopy, titration of thiol groups and elemental analysis. Our study took into consideration the synthesis parameters for the polymer networks, such as the total polymer concentration and the SH/C=C functionality molar ratio. Swelling in both THF and water was assessed, and the potential of the materials for drug delivery was determined. The scanning electron microscopy images showed that the prepared polymer networks may have different morphologies ranging from homogeneous polymer materials to macroporous structures. Additionally, the prepared materials were found to be suitable from a cytotoxicity point of view, enabling their application as biomaterials for drug delivery devices.
Institute of Chemistry Slovak Academy of Sciences Dúbravská cesta 9 845 38 Bratislava Slovakia
Polymer Institute of the Slovak Academy of Sciences Dubravska cesta 9 84541 Bratislava Slovakia
References provided by Crossref.org
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- $a The high interest in polymers from natural resources prompted us to investigate the use of enzymatically synthesized polyglobalide (PGL) in the preparation of polymer networks with potential applications as biomaterials for drug delivery devices. Polymer networks were obtained under mild conditions by photoinitiated thiol-ene coupling between PGL and a poly(ethylene glycol- co-thiomalate) (PEG-SH) copolymer obtained by polycondensation. The obtained polymer networks were thoroughly characterized by Raman spectroscopy, scanning electron microscopy, titration of thiol groups and elemental analysis. Our study took into consideration the synthesis parameters for the polymer networks, such as the total polymer concentration and the SH/C=C functionality molar ratio. Swelling in both THF and water was assessed, and the potential of the materials for drug delivery was determined. The scanning electron microscopy images showed that the prepared polymer networks may have different morphologies ranging from homogeneous polymer materials to macroporous structures. Additionally, the prepared materials were found to be suitable from a cytotoxicity point of view, enabling their application as biomaterials for drug delivery devices.
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