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Greener synthesis of Rod Shaped Zinc Oxide Nanoparticles using Lilium ledebourii tuber and evaluation of their Leishmanicidal activity
M. Khatami, S. Khatami, F. Mosazade, M. Raisi, M. Haghighat, M. Sabaghan, S. Yaghoubi, M. Sarani, M. Bamorovat, L. Malekian, A. Naroi, R. S Varma,
Language English Country Iran
Document type Journal Article
NLK
Free Medical Journals
from 2010
PubMed Central
from 2015
Europe PubMed Central
from 2015
- Publication type
- Journal Article MeSH
Background: Nanoparticles (NPs) with unique chemical and physical properties can be used for therapeutic purposes because of their strong antimicrobial activates. Nanoparticles have been used as an antimicrobial agents to inhibit microbial growth. Objectives: In view of the strong antimicrobial activity of nanoparticles, the biogenic synthesis and leishmanicidal activity of rod-shaped zinc oxide (R-ZnO) nanoparticles was explored using Lilium ledebourii tuber extract. Materials and Methods: The ensuing nanoparticles are characterized by UV-visible spectroscopy, X-ray diffraction and transmission electron microscopy and their leishmanicidal activity evaluated against the Leishmania major (L. major) by MTT assay. Results: The R-ZnO nanoparticles displayed excellent leishmanicidal activity against the L. major as they significantly inhibited the amastigotes. The IC50 values of R-ZnO nanoparticles being ~ 0.001 mg.mL-1. R-ZnO nanoparticles can inhibit L. major growth in a dose-dependent manner under in vitro conditions. Conclusion: A simple, low-cost feasible and eco-friendly procedure was developed for biosynthesis of R-ZnO nanoparticles using natural bioresource that can inhibit human parasite cells growth in a dose-dependent manner under in vitro conditions.
Behbahan Faculty of Medical Sciences Behbahan Iran
Clinical Research Center Pastor Educational Hospital Bam University of Medical Sciences Bam Iran
Department of Clinical Microbiology Iranshahr University of Medical Sciences Iranshahr Iran
Leishmaniasis Research Center Kerman University of Medical Sciences Kerman Iran
Noncommunicable Diseases Research Center Bam University of Medical Sciences Bam Iran
Student Research Committee School of Public Health Bam University of Medical Sciences Bam Iran
Zabol Medicinal Plants Research Center Zabol University of Medical Sciences Zabol Iran
References provided by Crossref.org
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- $a Khatami, Mehrdad $u Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran. Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran.
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- $a Background: Nanoparticles (NPs) with unique chemical and physical properties can be used for therapeutic purposes because of their strong antimicrobial activates. Nanoparticles have been used as an antimicrobial agents to inhibit microbial growth. Objectives: In view of the strong antimicrobial activity of nanoparticles, the biogenic synthesis and leishmanicidal activity of rod-shaped zinc oxide (R-ZnO) nanoparticles was explored using Lilium ledebourii tuber extract. Materials and Methods: The ensuing nanoparticles are characterized by UV-visible spectroscopy, X-ray diffraction and transmission electron microscopy and their leishmanicidal activity evaluated against the Leishmania major (L. major) by MTT assay. Results: The R-ZnO nanoparticles displayed excellent leishmanicidal activity against the L. major as they significantly inhibited the amastigotes. The IC50 values of R-ZnO nanoparticles being ~ 0.001 mg.mL-1. R-ZnO nanoparticles can inhibit L. major growth in a dose-dependent manner under in vitro conditions. Conclusion: A simple, low-cost feasible and eco-friendly procedure was developed for biosynthesis of R-ZnO nanoparticles using natural bioresource that can inhibit human parasite cells growth in a dose-dependent manner under in vitro conditions.
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- $a Khatami, Sanaz $u Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
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- $a S Varma, Rajender $u Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran. Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Clinical Research Center, Pastor Educational Hospital, Bam University of Medical Sciences, Bam, Iran. Behbahan Faculty of Medical Sciences, Behbahan, Iran. Department of Clinical Microbiology, Iranshahr University of Medical Sciences, Iranshahr, Iran. Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran. Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran. Student Research Committee, School of Public Health, Bam University of Medical Sciences, Bam, Iran. Regional Centre of Advanced Technologies and Materials Faculty of Science, Palacky University in Olomouc, Olomouc, Czech Republic.
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