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Anti-Müllerian hormone as an ovarian reserve marker in women with the most frequent muscular dystrophies

O. Parmova, E. Vlckova, M. Hulova, L. Mensova, I. Crha, P. Stradalova, E. Kralickova, L. Jurikova, M. Podborska, R. Mazanec, L. Dusek, J. Jarkovsky, J. Bednarik, S. Vohanka, I. Srotova,

. 2020 ; 99 (23) : e20523. [pub] 2020Jun05

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc20023003

Some muscular dystrophies may have a negative impact on fertility. A decreased ovarian reserve is 1 of the factors assumed to be involved in fertility impairment. AMH (anti-Müllerian hormone) is currently considered the best measure of ovarian reserve.A total of 21 females with myotonic dystrophy type 1 (MD1), 25 females with myotonic dystrophy type 2 (MD2), 12 females with facioscapulohumeral muscular dystrophy (FSHD), 12 female carriers of Duchenne muscular dystrophy mutations (cDMD) and 86 age-matched healthy controls of reproductive age (range 18 - 44 years) were included in this case control study. An enzymatically amplified 2-site immunoassay was used to measure serum AMH level.The MD1 group shows a significant decrease of AMH values (median 0.7 ng/mL; range 0 - 4.9 ng/mL) compared with age-matched healthy controls (P < .01). AMH levels were similar between patients and controls in terms of females with MD2 (P = .98), FSHD (P = .55) and cDMD (P = .60).This study suggests decreased ovarian reserve in women with MD1, but not in MD2, FSHD and cDMD.

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$a Some muscular dystrophies may have a negative impact on fertility. A decreased ovarian reserve is 1 of the factors assumed to be involved in fertility impairment. AMH (anti-Müllerian hormone) is currently considered the best measure of ovarian reserve.A total of 21 females with myotonic dystrophy type 1 (MD1), 25 females with myotonic dystrophy type 2 (MD2), 12 females with facioscapulohumeral muscular dystrophy (FSHD), 12 female carriers of Duchenne muscular dystrophy mutations (cDMD) and 86 age-matched healthy controls of reproductive age (range 18 - 44 years) were included in this case control study. An enzymatically amplified 2-site immunoassay was used to measure serum AMH level.The MD1 group shows a significant decrease of AMH values (median 0.7 ng/mL; range 0 - 4.9 ng/mL) compared with age-matched healthy controls (P < .01). AMH levels were similar between patients and controls in terms of females with MD2 (P = .98), FSHD (P = .55) and cDMD (P = .60).This study suggests decreased ovarian reserve in women with MD1, but not in MD2, FSHD and cDMD.
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$a Vlckova, Eva $u Department of Neurology, University Hospital Brno. Faculty of Medicine, Masaryk University, Brno. CEITEC - Central European Institute of Technology, Masaryk University, Brno. European Reference Network on Rare Neuromuscular Diseases (ERN EURO-NMD), Czechia.
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$a Hulova, Monika $u Department of Neurology, University Hospital Brno. Faculty of Medicine, Masaryk University, Brno.
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$a Mensova, Livie $u Department of Neurology, Second Faculty of Medicine, Charles University, Prague and University Hospital Motol, Prague. European Reference Network on Rare Neuromuscular Diseases (ERN EURO-NMD), Czechia.
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$a Crha, Igor $u Faculty of Medicine, Masaryk University, Brno. Department of Obstetrics and Gynaecology, University Hospital Brno.
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$a Stradalova, Petra $u Department of Neurology, University Hospital Brno. Faculty of Medicine, Masaryk University, Brno.
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$a Kralickova, Eva $u Department of Neurology, University Hospital Brno.
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$a Jurikova, Lenka $u Faculty of Medicine, Masaryk University, Brno. Department of Paediatric Neurology, Masaryk University and University Hospital Brno. European Reference Network on Rare Neuromuscular Diseases (ERN EURO-NMD), Czechia.
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$a Podborska, Martina $u Department of Clinical Biochemistry, University Hospital Brno.
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$a Mazanec, Radim $u Department of Paediatric Neurology, Masaryk University and University Hospital Brno. European Reference Network on Rare Neuromuscular Diseases (ERN EURO-NMD), Czechia.
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$a Dusek, Ladislav $u Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.
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$a Jarkovsky, Jiri $u Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.
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$a Bednarik, Josef $u Department of Neurology, University Hospital Brno. Faculty of Medicine, Masaryk University, Brno. CEITEC - Central European Institute of Technology, Masaryk University, Brno. European Reference Network on Rare Neuromuscular Diseases (ERN EURO-NMD), Czechia.
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$a Vohanka, Stanislav $u Department of Neurology, University Hospital Brno. Faculty of Medicine, Masaryk University, Brno. CEITEC - Central European Institute of Technology, Masaryk University, Brno. European Reference Network on Rare Neuromuscular Diseases (ERN EURO-NMD), Czechia.
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$a Srotova, Iva $u Department of Neurology, University Hospital Brno. Faculty of Medicine, Masaryk University, Brno. CEITEC - Central European Institute of Technology, Masaryk University, Brno. European Reference Network on Rare Neuromuscular Diseases (ERN EURO-NMD), Czechia.
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