A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis - Besse, Lenka; Besse, Andrej; Mendez-Lopez, Max; Vasickova, Katerina; Sedlackova, Miroslava; Vanhara, Petr; Kraus, Marianne; Bader, Jürgen; Ferreira, Renan B; Castellano, Ronald K; Law, Brian K; Driessen, Christoph (Haematologica, 2019)
Keywords: regulace genové exprese u nádorů; Hydrogen Peroxide; metabolomika; Antineoplastic Combined Chemotherapy Protocols; protokoly protinádorové kombinované chemoterapie; Humans; Mitochondria; lidé středního věku; nádorové buněčné linie; Antineoplastic Agents; Middle Aged; oligopeptidy; chemorezistence; Bortezomib; Homeostasis; protinádorové látky; Multiple Myeloma; Oligopeptides; Lipids; sfingomyeliny; peroxid vodíku; bortezomib; Metabolomics; Reactive Oxygen Species; mitochondrie; Proteasome Endopeptidase Complex; Protein Folding; sbalování proteinů; proteasomový endopeptidasový komplex; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; reaktivní formy kyslíku; inhibitory proteasomu; Sphingomyelins; ženské pohlaví; Female; stanovení celkové genové exprese; lidé; Cell Line, Tumor; Gene Expression Profiling; Proteasome Inhibitors; Aged; senioři; mnohočetný myelom; homeostáza; lipidy