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Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants
S. Tan, M. Abas, I. Verstraeten, M. Glanc, G. Molnár, J. Hajný, P. Lasák, I. Petřík, E. Russinova, J. Petrášek, O. Novák, J. Pospíšil, J. Friml,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Cell Press Free Archives
od 1995-01-01 do Před 1 rokem
Free Medical Journals
od 1995 do Před 1 rokem
Elsevier Open Access Journals
od 1995-01-01 do 2023-06-19
Elsevier Open Archive Journals
od 1995-01-01 do Před 1 rokem
- MeSH
- Arabidopsis růst a vývoj fyziologie MeSH
- imunita rostlin MeSH
- kořeny rostlin růst a vývoj metabolismus MeSH
- kyselina salicylová metabolismus MeSH
- kyseliny indoloctové metabolismus MeSH
- proteinfosfatasa 2 metabolismus MeSH
- proteiny huseníčku metabolismus MeSH
- signální transdukce * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense.
Center for Plant Systems Biology VIB 9052 Ghent Belgium
Department of Plant Biotechnology and Bioinformatics Ghent University 9052 Ghent Belgium
Institute of Science and Technology Austria Am Campus 1 3400 Klosterneuburg Austria
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- $a Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense.
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- $a Abas, Melinda $u Institute of Science and Technology Austria (IST Austria), Am Campus 1, 3400 Klosterneuburg, Austria; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences (BOKU), Muthgasse 18, 1190 Vienna, Austria.
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- $a Molnár, Gergely $u Institute of Science and Technology Austria (IST Austria), Am Campus 1, 3400 Klosterneuburg, Austria; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences (BOKU), Muthgasse 18, 1190 Vienna, Austria.
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- $a Hajný, Jakub $u Institute of Science and Technology Austria (IST Austria), Am Campus 1, 3400 Klosterneuburg, Austria; Laboratory of Growth Regulators, The Czech Academy of Sciences, Institute of Experimental Botany & Palacký University, Faculty of Science, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.
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- $a Pospíšil, Jiří $u Laboratory of Growth Regulators, The Czech Academy of Sciences, Institute of Experimental Botany & Palacký University, Faculty of Science, Šlechtitelů 27, 783 71 Olomouc, Czech Republic; Department of Organic Chemistry, Faculty of Science, Palacký University, tř. 17. listopadu 1192/12, CZ-771 46 Olomouc, Czech Republic.
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