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Action of carvacrol in Salmonella Typhimurium biofilm: A proteomic study

Daliah Alves Coelho Trevisan, Paula Aline Zanetti Campanerut-Sá, Alex Fiori da Silva, Andreia Farias Pereira Batista, Flavio Augusto Vicente Seixas, Rosane Marina Peralta, Anacharis Babeto de Sá-Nakanishi, Benício Alves de Abreu Filho, Miguel...

. 2020 ; 18 (4) : 106-114.

Jazyk angličtina Země Česko

Typ dokumentu klinická studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21009073

Carvacrol presents action in Salmonella Typhimurium biofilms, however the antibiofilm mechanism of this compound has not been fully established yet. In the present study, the aim was to evaluate protein profile changes in S. Typhimurium biofilm treated with carvacrol. Proteomic analysis of treated versus untreated biofilm showed several changes in proteins involved with S. Typhimurium biofilm and antioxidant activity. The proteins DsbA (thiol: disulfide interchange protein DsbA), LuxS (S-ribosylhomocysteine lyase), DksA (RNA polymerase binding transcription factor DksA), and SODs (superoxide dismutases) A, B and C had their synthesis decreased after treatment with carvacrol. These proteins play a key role in S. Typhimurium biofilm formation, demonstrating the dynamic antibiofilm action of carvacrol. The differentially expressed proteins identified provide possible action targets for future studies in order to gain more insight into the mechanism of action of carvacrol on S. Typhimurium biofilm.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

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