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High-Meat-Protein High-Fat Diet Induced Dysbiosis of Gut Microbiota and Tryptophan Metabolism in Wistar Rats
J. Shi, D. Zhao, S. Song, M. Zhang, G. Zamaratskaia, X. Xu, G. Zhou, C. Li
Language English Country United States
Document type Journal Article
- MeSH
- Bacteria classification genetics isolation & purification MeSH
- Cecum metabolism microbiology MeSH
- Diet, High-Fat adverse effects MeSH
- Dietary Proteins adverse effects metabolism MeSH
- Dysbiosis etiology metabolism microbiology MeSH
- Rats MeSH
- Humans MeSH
- Meat Proteins metabolism MeSH
- Rats, Wistar MeSH
- Gastrointestinal Microbiome * MeSH
- Tryptophan metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Meat-diet-induced changes in gut microbiota are often accompanied with the development of various metabolic and inflammatory disorders. The exact biochemical mechanism underlying these effects is not well elucidated. This study aims to evaluate how meat proteins in high-fat diets affect tryptophan metabolism in rats. The high-chicken-protein (HFHCH) or high-pork-protein (HFHP) diets increased levels of skatole and indole in cecal and colonic contents, feces, and subcutaneous adipose tissue. The HFHCH and HFHP diets also increased the abundance of Lactobacillus, the Family XIII AD3011 group, and Desulfovibrio in the cecum and colon, which may be involved in the production of skatole and indole. Additionally, high-meat-protein diets induced lower activity of skatole- and indole-metabolizing enzyme CYP2E1 in liver compared with low-meat-protein diets. This work highlights the negative impact of high meat proteins on physiological responses by inducing dysbiosis of gut microbiota and tryptophan metabolism.
Department of Molecular Sciences Swedish University of Agricultural Sciences 75007 Uppsala Sweden
Key Laboratory of Meat Processing and Quality Control Ministry of Education
Key Laboratory of Meat Processing Ministry of Agriculture and Rural Affairs
School of Food Science Nanjing Xiaozhuang University 211171 Nanjing P R China
References provided by Crossref.org
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