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Safety testing of adult novelties using in vitro methods
L. Svobodova, M. Dvorakova, M. Rucki, K. Kejlova, H. Kandarova, H. Kolarova, M. Mannerstrom, T. Heinonen
Language English Country Netherlands
Document type Journal Article
- MeSH
- BALB 3T3 Cells MeSH
- Endocrine Disruptors toxicity MeSH
- Fibroblasts drug effects physiology MeSH
- Play and Playthings * MeSH
- Humans MeSH
- Mice MeSH
- Pilot Projects MeSH
- Plastics toxicity MeSH
- Saccharomyces cerevisiae drug effects physiology MeSH
- Sexual Behavior drug effects physiology MeSH
- Consumer Product Safety standards MeSH
- In Vitro Techniques methods MeSH
- Toxicity Tests, Acute methods MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Despite widespread and prolonged use of adult novelties, their health safety is not regularly tested or legally regulated. In the EU, adult novelties are subjected to the General Product Safety Directive, placing the burden of proof regarding safe products onto the manufacturers. The aim of our pilot study was to expand knowledge on potential application of in vitro methods for hazard prediction of extracts from final products. We subjected extracts of 20 adult novelties, purchased on the Czech market to toxicological tests including NRU cytotoxicity assay, sensitization tests DPRA and LuSens and the YES/YAS endocrine assay. Four samples produced cytotoxicity. Sensitization potential was recorded by DPRA (three samples) while the LuSens reported ten samples. Regarding endocrine disruption, three samples produced antiestrogen and antiandrogen effects. Six samples exhibited androgenic potential and one sample showed estrogenic potential. Positive results with possible health effects were recorded repeatedly for samples made of ABS, PVC and latex. The study has confirmed promising usefulness of our test methods combination with regard to safety testing of this type of consumer products. The results should be evaluated with care, however, the data bring added-value to the limited knowledge of mixture toxicology and are indicative for further testing.
Charles University Prague 3rd Faculty of Medicine Ruská 87 100 00 Prague 10 Czech Republic
FICAM Faculty of Medicine and Health Technology FI 33014 Tampere University Tampere Finland
National Institute of Public Health Prague Šrobárova 48 49 100 00 Prague 10 Czech Republic
References provided by Crossref.org
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- $a Svobodová, Lada $u National Institute of Public Health, Prague, Šrobárova 48/49, 100 00, Prague 10, Czech Republic; Department of Medical Biophysics, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Czech Republic. Electronic address: lada.svobodova@szu.cz $7 xx0267259
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- $a Despite widespread and prolonged use of adult novelties, their health safety is not regularly tested or legally regulated. In the EU, adult novelties are subjected to the General Product Safety Directive, placing the burden of proof regarding safe products onto the manufacturers. The aim of our pilot study was to expand knowledge on potential application of in vitro methods for hazard prediction of extracts from final products. We subjected extracts of 20 adult novelties, purchased on the Czech market to toxicological tests including NRU cytotoxicity assay, sensitization tests DPRA and LuSens and the YES/YAS endocrine assay. Four samples produced cytotoxicity. Sensitization potential was recorded by DPRA (three samples) while the LuSens reported ten samples. Regarding endocrine disruption, three samples produced antiestrogen and antiandrogen effects. Six samples exhibited androgenic potential and one sample showed estrogenic potential. Positive results with possible health effects were recorded repeatedly for samples made of ABS, PVC and latex. The study has confirmed promising usefulness of our test methods combination with regard to safety testing of this type of consumer products. The results should be evaluated with care, however, the data bring added-value to the limited knowledge of mixture toxicology and are indicative for further testing.
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- $a Dvorakova, M $u National Institute of Public Health, Prague, Šrobárova 48/49, 100 00, Prague 10, Czech Republic; Charles University in Prague, Third Faculty of Medicine, Ruská 87, 100 00, Prague 10, Czech Republic. Electronic address: marketa.dvorakova@szu.cz
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- $a Kolarova, H $u Department of Medical Biophysics, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Czech Republic. Electronic address: hana.kolarova@upol.cz
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