• Je něco špatně v tomto záznamu ?

Could the musk compound tonalide affect physiological functions and act as an endocrine disruptor in rainbow trout

N. Hodkovicova, V. Enevova, J. Cahova, J. Blahova, Z. Siroka, L. Plhalova, V. Doubkova, P. Marsalek, A. Franc, E. Fiorino, C. Faggio, F. Tichy, M. Faldyna, Z. Svobodova

. 2020 ; 69 (Suppl 4) : S595-S606. [pub] 20201231

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21028109

In the present study, the effect of polycyclic musk compound tonalide (AHTN) in two concentrations was studied in male rainbow trout (Oncorhynchus mykiss, Walbaum 1792). A feeding trial was conducted with AHTN incorporated into feed granules. One concentration was environmentally relevant (854 µg/kg); the second one was 10× higher (8699 µg/kg). The fish were fed twice a day with the amount of feed at 1 % of their body weight. After an acclimatization period, the experimental phase in duration of six weeks followed. At the end of the experiment, fish were sampled and the biometrical data were recorded. Subsequently, hematological and biochemical tests, histopathological examination, analysis of oxidative stress markers and evaluation of endocrine disruption using plasma vitellogenin were performed. In conclusion, an increase of hematocrit for both AHTN concentrations was found, but no significant changes were observed in biochemical profile. Moreover, AHTN caused lipid peroxidation in caudal kidney tissue, which was confirmed by histopathological images. The long-lasting AHTN exposure could thus be harmful for maintaining homeostasis in the rainbow trout organism. However, the vitellogenin concentration seemed not to be affected by AHTN.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc21028109
003      
CZ-PrNML
005      
20211202140500.0
007      
ta
008      
211105s2020 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934608 $2 doi
035    __
$a (PubMed)33656906
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Hodkovicová, Nikola $7 ola20211102302 $u Veterinary Research Institute, Brno, Czech Republic
245    10
$a Could the musk compound tonalide affect physiological functions and act as an endocrine disruptor in rainbow trout / $c N. Hodkovicova, V. Enevova, J. Cahova, J. Blahova, Z. Siroka, L. Plhalova, V. Doubkova, P. Marsalek, A. Franc, E. Fiorino, C. Faggio, F. Tichy, M. Faldyna, Z. Svobodova
504    __
$a Literatura
520    9_
$a In the present study, the effect of polycyclic musk compound tonalide (AHTN) in two concentrations was studied in male rainbow trout (Oncorhynchus mykiss, Walbaum 1792). A feeding trial was conducted with AHTN incorporated into feed granules. One concentration was environmentally relevant (854 µg/kg); the second one was 10× higher (8699 µg/kg). The fish were fed twice a day with the amount of feed at 1 % of their body weight. After an acclimatization period, the experimental phase in duration of six weeks followed. At the end of the experiment, fish were sampled and the biometrical data were recorded. Subsequently, hematological and biochemical tests, histopathological examination, analysis of oxidative stress markers and evaluation of endocrine disruption using plasma vitellogenin were performed. In conclusion, an increase of hematocrit for both AHTN concentrations was found, but no significant changes were observed in biochemical profile. Moreover, AHTN caused lipid peroxidation in caudal kidney tissue, which was confirmed by histopathological images. The long-lasting AHTN exposure could thus be harmful for maintaining homeostasis in the rainbow trout organism. However, the vitellogenin concentration seemed not to be affected by AHTN.
650    _2
$a zvířata $7 D000818
650    _2
$a vztah mezi dávkou a účinkem léčiva $7 D004305
650    _2
$a endokrinní disruptory $x toxicita $7 D052244
650    _2
$a kyseliny mastné mononenasycené $x toxicita $7 D005229
650    _2
$a rybí proteiny $x krev $7 D029941
650    _2
$a žábry $x účinky léků $x metabolismus $x patologie $7 D005880
650    _2
$a ledviny $x účinky léků $x metabolismus $x patologie $7 D007668
650    _2
$a peroxidace lipidů $x účinky léků $7 D015227
650    _2
$a játra $x účinky léků $x metabolismus $x patologie $7 D008099
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a Oncorhynchus mykiss $x krev $x metabolismus $7 D017686
650    _2
$a oxidační stres $x účinky léků $7 D018384
650    _2
$a tetrahydronaftaleny $x toxicita $7 D013764
650    _2
$a vitelogeniny $x krev $7 D014819
655    _2
$a časopisecké články $7 D016428
700    1_
$a Enevová, Vladimíra $7 xx0266890 $u Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
700    1_
$a Cahová, Jana $7 xx0267007 $u Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
700    1_
$a Blahová, Jana, $d 1980- $7 mzk2012705837 $u Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
700    1_
$a Široká, Zuzana $7 xx0040403 $u Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
700    1_
$a Plhalová, Lucie $7 xx0171557 $u Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
700    1_
$a Doubková, Veronika $7 xx0267030 $u Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
700    1_
$a Maršálek, Petr, $d 1976- $7 xx0050584 $u Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
700    1_
$a Franc, Aleš, $d 1968- $7 mzk2008479726 $u Department of Pharmaceutics, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic
700    1_
$a Fiorino, E. $u Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy
700    1_
$a Faggio, C. $u Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy
700    1_
$a Tichý, František $7 jn20001103442 $u Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
700    1_
$a Faldyna, Martin $7 xx0047099 $u Department of Infectious Diseases and Preventive Medicine, Veterinary Research Institute, Brno, Czech Republic
700    1_
$a Svobodová, Zdeňka, $d 1943- $7 jx20031130138 $u Department of Animal Protection and Welfare & Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 69, Suppl 4 (2020), s. S595-S606
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33656906 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20211105 $b ABA008
991    __
$a 20211202140455 $b ABA008
999    __
$a ok $b bmc $g 1728722 $s 1148654
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 69 $c Suppl 4 $d S595-S606 $e 20201231 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20211105

Najít záznam

Citační ukazatele

Možnosti archivace