Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Pineal gland calcification under hypoxic conditions

M. Kopáni, B. Vraníková, D. Kosnáč, M. Zeman, V. Šišovský, S. Polakovičová, C. Biró

. 2019 ; 68 (Suppl 4) : S405-S413. [pub] 20191230
. 2019 ; () : S405-S413.

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21028210

The pineal gland (glandula pinealis) is neuroendocrine gland located at the epithalamus of the brain secreting melatonin. The aim of this study was to explore effects of prenatal hypoxia in rats at the age of 33 weeks on the occurrence of pineal gland calcification. Distribution and chemical composition of calcerous material by light, scanning and transmission electron microscopy was investigated. Melatonin concentrations in blood plasma by direct radioimmunoassay were measured. Rats were exposed to prenatal hypoxia for 12 h at day 20 of development and second group to prenatal hypoxia for 2x8 h at days 19 and 20 of development. Vacuoles of intracellular edema in the pineal samples after 12 h hypoxia were found. Their size ranges up to 30 μm. Some of them were filled with the flocculent and fibrous material. Samples of pineal glands after 2 x 8 h hypoxia revealed the pericellular edema of pinealocytes. The amount of calcium rich particles in 2 x 8 h hypoxia group was lower than in 12 h hypoxia group. Plasma melatonin levels did not differ between control and both hypoxia groups. We concluded that calcification is a process induced by osteoblasts and osteocytes with melatonin as a promotor and it is favored under hypoxic conditions.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc21028210
003      
CZ-PrNML
005      
20220325111004.0
007      
ta
008      
211105s2019 xr a f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934378 $2 doi
035    __
$a (PubMed)32118471
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Kopáni, Martin $7 xx0078268 $u Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
245    10
$a Pineal gland calcification under hypoxic conditions / $c M. Kopáni, B. Vraníková, D. Kosnáč, M. Zeman, V. Šišovský, S. Polakovičová, C. Biró
504    __
$a Literatura
520    9_
$a The pineal gland (glandula pinealis) is neuroendocrine gland located at the epithalamus of the brain secreting melatonin. The aim of this study was to explore effects of prenatal hypoxia in rats at the age of 33 weeks on the occurrence of pineal gland calcification. Distribution and chemical composition of calcerous material by light, scanning and transmission electron microscopy was investigated. Melatonin concentrations in blood plasma by direct radioimmunoassay were measured. Rats were exposed to prenatal hypoxia for 12 h at day 20 of development and second group to prenatal hypoxia for 2x8 h at days 19 and 20 of development. Vacuoles of intracellular edema in the pineal samples after 12 h hypoxia were found. Their size ranges up to 30 μm. Some of them were filled with the flocculent and fibrous material. Samples of pineal glands after 2 x 8 h hypoxia revealed the pericellular edema of pinealocytes. The amount of calcium rich particles in 2 x 8 h hypoxia group was lower than in 12 h hypoxia group. Plasma melatonin levels did not differ between control and both hypoxia groups. We concluded that calcification is a process induced by osteoblasts and osteocytes with melatonin as a promotor and it is favored under hypoxic conditions.
650    _2
$a zvířata $7 D000818
650    12
$a kalcinóza $7 D002114
650    _2
$a hypoxie $x metabolismus $7 D000860
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a epifýza mozková $x metabolismus $x ultrastruktura $7 D010870
650    _2
$a potkani Wistar $7 D017208
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vraníková, Barbora, $d 1987- $7 xx0228025 $u Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
700    1_
$a Kosnáč, Daniel. $7 xx0267737 $u Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
700    1_
$a Zeman, Michal, $d 1952- $7 xx0054393 $u Department of Animal Physiology and Ethology, Faculty of Natural Science, Comenius University, Bratislava, Slovakia
700    1_
$a Šišovský, Vladimír $7 xx0104743 $u Institute of Pathological Anatomy, Faculty of Medicine, Comenius University, Bratislava, Slovakia
700    1_
$a Polakovičová, Simona $7 xx0174995 $u Institute of Institute of Histology and Embryology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
700    1_
$a Biró, Csaba $7 jo2015855141 $u Department of Pathology, Institute of Oncology St. Elizabeth, Bratislava, Slovakia
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 68, Suppl 4 (2019), s. S405-S413
773    0_
$t Contemporary Czech and Slovak research on medical biophysics $g (2019), s. S405-S413 $w MED00208906
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32118471 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20211105 $b ABA008
991    __
$a 20220325110956 $b ABA008
999    __
$a ok $b bmc $g 1735530 $s 1148755
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 68 $c Suppl 4 $d S405-S413 $e 20191230 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
BMC    __
$a 2019 $d S405-S413 $m Contemporary Czech and Slovak research on medical biophysics $x MED00208906
LZP    __
$b NLK118 $a Pubmed-20211105

Find record

Citation metrics

Archiving options