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Amine modification of calcium phosphate by low-pressure plasma for bone regeneration

J. Kodama, AA. Harumningtyas, T. Ito, M. Michlíček, S. Sugimoto, H. Kita, R. Chijimatsu, Y. Ukon, J. Kushioka, R. Okada, T. Kamatani, K. Hashimoto, D. Tateiwa, H. Tsukazaki, S. Nakagawa, S. Takenaka, T. Makino, Y. Sakai, D. Nečas, L. Zajíčková,...

. 2021 ; 11 (1) : 17870. [pub] 20210909

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc22003752

Regeneration of large bone defects caused by trauma or tumor resection remains one of the biggest challenges in orthopedic surgery. Because of the limited availability of autograft material, the use of artificial bone is prevalent; however, the primary role of currently available artificial bone is restricted to acting as a bone graft extender owing to the lack of osteogenic ability. To explore whether surface modification might enhance artificial bone functionality, in this study we applied low-pressure plasma technology as next-generation surface treatment and processing strategy to chemically (amine) modify the surface of beta-tricalcium phosphate (β-TCP) artificial bone using a CH4/N2/He gas mixture. Plasma-treated β-TCP exhibited significantly enhanced hydrophilicity, facilitating the deep infiltration of cells into interconnected porous β-TCP. Additionally, cell adhesion and osteogenic differentiation on the plasma-treated artificial bone surfaces were also enhanced. Furthermore, in a rat calvarial defect model, the plasma treatment afforded high bone regeneration capacity. Together, these results suggest that amine modification of artificial bone by plasma technology can provide a high osteogenic ability and represents a promising strategy for resolving current clinical limitations regarding the use of artificial bone.

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$a Kodama, Joe $u Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
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$a Amine modification of calcium phosphate by low-pressure plasma for bone regeneration / $c J. Kodama, AA. Harumningtyas, T. Ito, M. Michlíček, S. Sugimoto, H. Kita, R. Chijimatsu, Y. Ukon, J. Kushioka, R. Okada, T. Kamatani, K. Hashimoto, D. Tateiwa, H. Tsukazaki, S. Nakagawa, S. Takenaka, T. Makino, Y. Sakai, D. Nečas, L. Zajíčková, S. Hamaguchi, T. Kaito
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$a Regeneration of large bone defects caused by trauma or tumor resection remains one of the biggest challenges in orthopedic surgery. Because of the limited availability of autograft material, the use of artificial bone is prevalent; however, the primary role of currently available artificial bone is restricted to acting as a bone graft extender owing to the lack of osteogenic ability. To explore whether surface modification might enhance artificial bone functionality, in this study we applied low-pressure plasma technology as next-generation surface treatment and processing strategy to chemically (amine) modify the surface of beta-tricalcium phosphate (β-TCP) artificial bone using a CH4/N2/He gas mixture. Plasma-treated β-TCP exhibited significantly enhanced hydrophilicity, facilitating the deep infiltration of cells into interconnected porous β-TCP. Additionally, cell adhesion and osteogenic differentiation on the plasma-treated artificial bone surfaces were also enhanced. Furthermore, in a rat calvarial defect model, the plasma treatment afforded high bone regeneration capacity. Together, these results suggest that amine modification of artificial bone by plasma technology can provide a high osteogenic ability and represents a promising strategy for resolving current clinical limitations regarding the use of artificial bone.
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$a Ito, Tomoko $u Center for Atomic and Molecular Technologies (CAMT), Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan
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$a Michlíček, Miroslav $u Department of Physical Electronics, Faculty of Science, Masaryk University, Kotlarska 2, 61137, Brno, Czech Republic
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$a Sugimoto, Satoshi $u Center for Atomic and Molecular Technologies (CAMT), Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan
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$a Chijimatsu, Ryota $u Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan $u Bone and Cartilage Regenerative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
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$a Kamatani, Takashi $u Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
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$a Hashimoto, Kunihiko $u Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
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$a Tateiwa, Daisuke $u Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
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$a Nečas, David $u CEITEC - Central European Institute of Technology, Brno University of Technology, Purkynova 123, Brno, 61200, Czech Republic
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$a Zajíčková, Lenka $u CEITEC - Central European Institute of Technology, Brno University of Technology, Purkynova 123, Brno, 61200, Czech Republic $u Department of Condensed Matter Physics, Faculty of Science, Masaryk University, Kotlarska 2, Brno, 61137, Czech Republic
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