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Does GD2 synthase (GD2S) detect cancer stem cells in blood samples of breast carcinomas?

Maryam Mansoori, Isa Abdi Rad, Alireza Mirzaei, Kevin J. Tam, Seyed Mohsen Hosseini, Rahim Mahmodlu, Fatemeh Mansouri, Leili Saeednejad Zanjani, Zahra Madjd

. 2021 ; 19 (4) : 181-189.

Language English Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc22007588

Introduction: Cancer stem cells (CSCs) are a theorized subset of cells within the tumor that is thought to drive disease recurrence and metastatic spread. The aim of this study is to investigate mRNA and protein levels of ganglioside GD2 synthase (GD2S), in breast cancer (BC) patients. Methods: 65 PBMCs of preoperative BC patients without chemotherapy were compared to PBMCs after chemotherapy and controls. Results: GD2S were significantly higher in BC patients after chemotherapy compared to pre-chemotherapy at both mRNA and protein. GD2S was higher in pre-chemotherapy blood samples compared to control samples. Conclusions: Higher expression of GD2S in BC samples compared to healthy control indicates the potential utility of GD2S as a marker of malignancy.

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$a Mansoori, Maryam $u Iran University of Medical Sciences, Oncopathology Research Center, Tehran, Iran; Iran University of Medical Sciences, Faculty of Advanced Technologies in Medicine, Department of Molecular Medicine, Tehran, Iran
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$a Introduction: Cancer stem cells (CSCs) are a theorized subset of cells within the tumor that is thought to drive disease recurrence and metastatic spread. The aim of this study is to investigate mRNA and protein levels of ganglioside GD2 synthase (GD2S), in breast cancer (BC) patients. Methods: 65 PBMCs of preoperative BC patients without chemotherapy were compared to PBMCs after chemotherapy and controls. Results: GD2S were significantly higher in BC patients after chemotherapy compared to pre-chemotherapy at both mRNA and protein. GD2S was higher in pre-chemotherapy blood samples compared to control samples. Conclusions: Higher expression of GD2S in BC samples compared to healthy control indicates the potential utility of GD2S as a marker of malignancy.
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$a Rad, Isa Abdi $u Urmia University of Medical Sciences, Cellular and Molecular Research Center, Urmia, Iran
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$a Mirzaei, Alireza $u Iran University of Medical Sciences, Shafa Orthopedic Hospital, Bone and Joint Reconstruction Research Center, Tehran, Iran
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$a Tam, Kevin J. $u University of British Columbia, Vancouver Prostate Centre, Department of Urologic Sciences, Vancouver, Canada
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$a Hosseini, Seyed Mohsen $u Omid specialty and subspecialty Hospital, Oncology and Radiotherapy Ward, Urmia, Iran
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$a Mahmodlu, Rahim $u Urmia University of Medical Sciences, Faculty of Medicine, Imam Khomeini Hospital, Department of Surgery, Urmia, Iran
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$a Mansouri, Fatemeh $u Urmia University of Medical Sciences, Faculty of Medicine, Department of Genetics and Immunology, Urmia, Iran
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