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5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
M. Yusefi, MS. Lee-Kiun, K. Shameli, SY. Teow, RR. Ali, KK. Siew, HY. Chan, MM. Wong, WL. Lim, K. Kuča
Carbohydrate polymers.
2021 ;
273 (-) :
118523.
[pub] 20210804
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc22011786
- MeSH
- buňky HT-29 MeSH
- celulosa chemie MeSH
- fluoruracil chemie farmakologie MeSH
- HCT116 buňky MeSH
- kolorektální nádory farmakoterapie metabolismus MeSH
- lékové transportní systémy metody MeSH
- lidé MeSH
- magnetické jevy MeSH
- magnetické nanočástice oxidů železa chemie MeSH
- mikroskopie elektronová rastrovací metody MeSH
- nanokompozity chemie MeSH
- nosiče léků chemie MeSH
- polymery chemie MeSH
- protinádorové látky farmakologie MeSH
- uvolňování léčiv MeSH
- viabilita buněk účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments.
Citace poskytuje Crossref.org
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