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European Association of Urology (EAU) Prognostic Factor Risk Groups for Non-muscle-invasive Bladder Cancer (NMIBC) Incorporating the WHO 2004/2016 and WHO 1973 Classification Systems for Grade: An Update from the EAU NMIBC Guidelines Panel
RJ. Sylvester, O. Rodríguez, V. Hernández, D. Turturica, L. Bauerová, HM. Bruins, J. Bründl, TH. van der Kwast, A. Brisuda, J. Rubio-Briones, M. Seles, AE. Hentschel, VRM. Kusuma, N. Huebner, J. Cotte, LS. Mertens, D. Volanis, O. Cussenot, JD....
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
- MeSH
- invazivní růst nádoru MeSH
- lidé MeSH
- nádory močového měchýře * terapie MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- Světová zdravotnická organizace MeSH
- urologie * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: The European Association of Urology (EAU) prognostic factor risk groups for non-muscle-invasive bladder cancer (NMIBC) are used to provide recommendations for patient treatment after transurethral resection of bladder tumor (TURBT). They do not, however, take into account the widely used World Health Organization (WHO) 2004/2016 grading classification and are based on patients treated in the 1980s. OBJECTIVE: To update EAU prognostic factor risk groups using the WHO 1973 and 2004/2016 grading classifications and identify patients with the lowest and highest probabilities of progression. DESIGN, SETTING, AND PARTICIPANTS: Individual patient data for primary NMIBC patients were collected from the institutions of the members of the EAU NMIBC guidelines panel. INTERVENTION: Patients underwent TURBT followed by intravesical instillations at the physician's discretion. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Multivariable Cox proportional-hazards regression models were fitted to the primary endpoint, the time to progression to muscle-invasive disease or distant metastases. Patients were divided into four risk groups: low-, intermediate-, high-, and a new, very high-risk group. The probabilities of progression were estimated using Kaplan-Meier curves. RESULTS AND LIMITATIONS: A total of 3401 patients treated with TURBT ± intravesical chemotherapy were included. From the multivariable analyses, tumor stage, WHO 1973/2004-2016 grade, concomitant carcinoma in situ, number of tumors, tumor size, and age were used to form four risk groups for which the probability of progression at 5 yr varied from <1% to >40%. Limitations include the retrospective collection of data and the lack of central pathology review. CONCLUSIONS: This study provides updated EAU prognostic factor risk groups that can be used to inform patient treatment and follow-up. Incorporating the WHO 2004/2016 and 1973 grading classifications, a new, very high-risk group has been identified for which urologists should be prompt to assess and adapt their therapeutic strategy when necessary. PATIENT SUMMARY: The newly updated European Association of Urology prognostic factor risk groups for non-muscle-invasive bladder cancer provide an improved basis for recommending a patient's treatment and follow-up schedule.
Department of Health Evidence Radboud University Medical Center Nijmegen The Netherlands
Department of Pathology Caritas St Josef Medical Center University of Regensburg Regensburg Germany
Department of Pathology Fundacio Puigvert Universitat Autònoma de Barcelona Barcelona Spain
Department of Pathology Fundación Instituto Valenciano de Oncología Valencia Spain
Department of Pathology Hospital Universitario Fundación Alcorcón Madrid Spain
Department of Pathology Medical University of Graz Graz Austria
Department of Pathology Radboud University Medical Center Nijmegen The Netherlands
Department of Pathology Royal Free London NHS Foundation Trust Royal Free Hospital London UK
Department of Pathology Tenon Hospital AP HP Sorbonne University Paris France
Department of Urology Caritas St Josef Medical Center University of Regensburg Regensburg Germany
Department of Urology Fundacio Puigvert Universitat Autònoma de Barcelona Barcelona Spain
Department of Urology Fundación Instituto Valenciano de Oncología Valencia Spain
Department of Urology Hospital Universitario Fundación Alcorcón Madrid Spain
Department of Urology Medical University of Graz Graz Austria
Department of Urology Pitié Salpétrière Hospital AP HP Sorbonne University Paris France
Department of Urology Radboud University Medical Center Nijmegen The Netherlands
Department of Urology Royal Free London NHS Foundation Trust Royal Free Hospital London UK
Department of Urology Tenon Hospital AP HP Sorbonne University Paris France
Department of Urology The Stokes Centre for Urology Royal Surrey Hospital Guildford UK
European Association of Urology Guidelines Office Arnhem The Netherlands
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- $a Sylvester, Richard J $u European Association of Urology Non-Muscle-Invasive Bladder Cancer Guidelines Panel, Arnhem, The Netherlands. Electronic address: richard.sylvester@skynet.be
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- $a European Association of Urology (EAU) Prognostic Factor Risk Groups for Non-muscle-invasive Bladder Cancer (NMIBC) Incorporating the WHO 2004/2016 and WHO 1973 Classification Systems for Grade: An Update from the EAU NMIBC Guidelines Panel / $c RJ. Sylvester, O. Rodríguez, V. Hernández, D. Turturica, L. Bauerová, HM. Bruins, J. Bründl, TH. van der Kwast, A. Brisuda, J. Rubio-Briones, M. Seles, AE. Hentschel, VRM. Kusuma, N. Huebner, J. Cotte, LS. Mertens, D. Volanis, O. Cussenot, JD. Subiela Henríquez, E. de la Peña, F. Pisano, M. Pešl, AG. van der Heijden, S. Herdegen, AR. Zlotta, J. Hacek, A. Calatrava, S. Mannweiler, J. Bosschieter, D. Ashabere, A. Haitel, JF. Côté, S. El Sheikh, L. Lunelli, F. Algaba, I. Alemany, F. Soria, W. Runneboom, J. Breyer, JA. Nieuwenhuijzen, C. Llorente, L. Molinaro, CA. Hulsbergen-van de Kaa, M. Evert, LALM. Kiemeney, J. N'Dow, K. Plass, O. Čapoun, V. Soukup, JL. Dominguez-Escrig, D. Cohen, J. Palou, P. Gontero, M. Burger, R. Zigeuner, AH. Mostafid, SF. Shariat, M. Rouprêt, EM. Compérat, M. Babjuk, BWG. van Rhijn
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