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The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes

M. Ješeta, K. Franzová, S. Machynová, J. Kalina, J. Kohoutek, L. Mekiňová, I. Crha, B. Kempisty, M. Kašík, J. Žáková, P. Ventruba, J. Navrátilová

. 2022 ; 10 (6) : . [pub] 20220609

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22016998

Grantová podpora
FNBr, 65269705, AZV NV18-01-00544 Czech Ministry of Health
CZ.02.2.69/0.0/0.0/19_074/0012727 MSCAfellow3@MUNI
LM2018121 Research Infrastructure RECETOX RI
CETOCOEN EXCELLENCE (No CZ.02.1.01/0.0/0.0/17_043/0009632 Ministry of Education, Youth and Sports, and Operational Programme Research, Development and Innovation

Exposure to bisphenols is related to negative effects on male reproduction. The bisphenols exposure is associated with several modes of action including negative impact on the blood-testis barrier (BTB) in testes or direct effect on spermatozoa. Bisphenols have been detected in human seminal plasma, but the possible mechanism of seminal transfer of bisphenols is not clear. Some authors consider the transfer through the blood-testis barrier to be crucial. Therefore, in this work, we compared normozoospermic men and men after vasectomy who have interrupted vas deferens and their ejaculate does not contain testicular products. We measured the concentration of bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) in the urine and seminal plasma of these men using liquid chromatography tandem mass spectrometry (LC/MSMS). We found that the ratio of urinary and seminal plasma content of bisphenols did not differ in normozoospermic men or men after vasectomy. From the obtained data, it can be concluded that the pathways of transport of bisphenols into seminal plasma are not primarily through the testicular tissue, but this pathway is applied similarly to other routes of transmission by a corresponding ejaculate volume ratio. To a much greater extent than through testicular tissue, bisphenols enter the seminal plasma mainly as part of the secretions of the accessory glands.

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$a Ješeta, Michal $u Center of Assisted Reproduction, Department of Gynecology and Obstetrics, Masaryk University Brno and University Hospital Brno, 62500 Brno, Czech Republic $u Department of Veterinary Sciences, Czech University of Life Sciences in Prague, 16500 Prague, Czech Republic
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$a Exposure to bisphenols is related to negative effects on male reproduction. The bisphenols exposure is associated with several modes of action including negative impact on the blood-testis barrier (BTB) in testes or direct effect on spermatozoa. Bisphenols have been detected in human seminal plasma, but the possible mechanism of seminal transfer of bisphenols is not clear. Some authors consider the transfer through the blood-testis barrier to be crucial. Therefore, in this work, we compared normozoospermic men and men after vasectomy who have interrupted vas deferens and their ejaculate does not contain testicular products. We measured the concentration of bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) in the urine and seminal plasma of these men using liquid chromatography tandem mass spectrometry (LC/MSMS). We found that the ratio of urinary and seminal plasma content of bisphenols did not differ in normozoospermic men or men after vasectomy. From the obtained data, it can be concluded that the pathways of transport of bisphenols into seminal plasma are not primarily through the testicular tissue, but this pathway is applied similarly to other routes of transmission by a corresponding ejaculate volume ratio. To a much greater extent than through testicular tissue, bisphenols enter the seminal plasma mainly as part of the secretions of the accessory glands.
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