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The Tale-Tell Heart: Evolutionary tetrapod shift from aquatic to terrestrial life-style reflected in heart changes in axolotl (Ambystoma mexicanum)
V. Olejnickova, H. Kolesova, M. Bartos, D. Sedmera, M. Gregorovicova
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1992 to 1 year ago
Medline Complete (EBSCOhost)
from 2012-07-01 to 1 year ago
Wiley Free Content
from 1996 to 1 year ago
PubMed
34423892
DOI
10.1002/dvdy.413
Knihovny.cz E-resources
- MeSH
- Ambystoma mexicanum * physiology MeSH
- Biological Evolution MeSH
- Metamorphosis, Biological physiology MeSH
- Myocardium MeSH
- Heart * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: During amphibian metamorphosis, the crucial moment lies in the rearrangement of the heart, reflecting the changes in circulatory demands. However, little is known about the exact shifts linked with this rearrangement. Here, we demonstrate such myocardial changes in axolotl (Ambystoma mexicanum) from the morphological and physiological point of view. RESULTS: Micro-CT and histological analysis showed changes in ventricular trabeculae organization, completion of the atrial septum and its connection to the atrioventricular valve. Based on Myosin Heavy Chain and Smooth Muscle Actin expression we distinguished metamorphosis-induced changes in myocardial differentiation at the ventricular trabeculae and atrioventricular canal. Using optical mapping, faster speed of conduction through the atrioventricular canal was demonstrated in metamorphic animals. No differences between the groups were observed in the heart rates, ventricular activation times, and activation patterns. CONCLUSIONS: Transition from aquatic to terrestrial life-style is reflected in the heart morphology and function. Rebuilding of the axolotl heart during metamorphosis was connected with reorganization of ventricular trabeculae, completion of the atrial septum and its connection to the atrioventricular valve, and acceleration of AV conduction.
1st Faculty of Medicine Institute of Anatomy Charles University Prague Czech Republic
1st Faculty of Medicine Institute of Dental Medicine Charles University Prague Czech Republic
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