BACKGROUND: Dementia syndrome is one of the most devastating conditions in older adults. As treatments to stop neurodegeneration become available, accurate and timely diagnosis will increase in importance. One issue is that cognitive performance sometimes does not match the corresponding level of neuropathology, affecting diagnostic accuracy. Cognitive reserve (CR), which can preserve cognitive function despite underlying neuropathology, explains at least some variability in cognitive performance. We examined the influence of CR proxies (education and occupational position) on the relationship between hippocampal or total gray matter volume and cognition. METHODS: We used data from the Czech Brain Aging Study. Participants were clinically confirmed to be without dementia (n = 457, including subjective cognitive decline and amnestic mild cognitive impairment) or with dementia syndrome (n = 113). RESULTS: For participants without dementia, higher education magnified the associations between (a) hippocampal volume and executive control (b = 0.09, p = 0.033), (b) total gray matter volume and language (b = 0.12, p < 0.001), and (c) total gray matter volume and memory (b = 0.08, p = 0.018). Similarly, higher occupational position magnified the association between total gray matter volume and (a) attention/working memory (b = 0.09, p = 0.009), (b) language (b = 0.13, p = 0.002), and (c) memory (b = 0.10, p = 0.013). For participants with dementia, the associations between hippocampal (b = -0.26, p = 0.024) and total gray matter (b = -0.28, p = 0.024) volume and visuospatial skills decreased in magnitude with higher education. CONCLUSION: We found that the association between brain volume and cognitive performance varies based on CR, with greater CR related to a stronger link between brain volume and cognition before, and a weaker link after, dementia diagnosis.

Department of Neurology 2nd Faculty of Medicine Charles University and Motol University Hospital Prague Czechia

Edson College of Nursing and Health Innovation Arizona State University Phoenix AZ United States

School of Aging Studies University of South Florida Tampa FL United States

000      

00000naa a2200000 a 4500

001      

bmc22031357

003      

CZ-PrNML

005      

20230815091002.0

007      

ta

008      

230119s2022 sz f 000 0|eng||

009      

AR

024    7_

$a 10.3389/fnagi.2022.1018071 $2 doi

035    __

$a (PubMed)36408097

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a sz

100    1_

$a Nelson, Monica E $u School of Aging Studies, University of South Florida, Tampa, FL, United States

245    10

$a Moderating effect of cognitive reserve on brain integrity and cognitive performance / $c ME. Nelson, BM. Veal, R. Andel, J. Martinkova, K. Veverova, H. Horakova, Z. Nedelska, J. Laczó, M. Vyhnalek, J. Hort

520    9_

$a BACKGROUND: Dementia syndrome is one of the most devastating conditions in older adults. As treatments to stop neurodegeneration become available, accurate and timely diagnosis will increase in importance. One issue is that cognitive performance sometimes does not match the corresponding level of neuropathology, affecting diagnostic accuracy. Cognitive reserve (CR), which can preserve co $a BACKGROUND Dementia syndrome is one of the most devastating conditions in older adults As treatments to stop neurodegeneration become available accurate and timely diagnosis will increase in importance One issue is that cognitive performance sometimes does not match the corresponding level of neuropathology affecting diagnostic accuracy Cognitive reserve CR which can preserve cognitive f $a BACKGROUND: Dementia syndrome is one of the most devastating conditions in older adults. As treatments to stop neurodegeneration become available, accurate and timely diagnosis will increase in importance. One issue is that cognitive performance sometimes does not match the corresponding level of neuropathology, affecting diagnostic accuracy. Cognitive reserve (CR), which can preserve cognitive function despite underlying neuropathology, explains at least some variability in cognitive performance. We examined the influence of CR proxies (education and occupational position) on the relationship between hippocampal or total gray matter volume and cognition. METHODS: We used data from the Czech Brain Aging Study. Participants were clinically confirmed to be without dementia (n = 457, including subjective cognitive decline and amnestic mild cognitive impairment) or with dementia syndrome (n = 113). RESULTS: For participants without dementia, higher education magnified the associations between (a) hippocampal volume and executive control (b = 0.09, p = 0.033), (b) total gray matter volume and language (b = 0.12, p < 0.001), and (c) total gray matter volume and memory (b = 0.08, p = 0.018). Similarly, higher occupational position magnified the association between total gray matter volume and (a) attention/working memory (b = 0.09, p = 0.009), (b) language (b = 0.13, p = 0.002), and (c) memory (b = 0.10, p = 0.013). For participants with dementia, the associations between hippocampal (b = -0.26, p = 0.024) and total gray matter (b = -0.28, p = 0.024) volume and visuospatial skills decreased in magnitude with higher education. CONCLUSION: We found that the association between brain volume and cognitive performance varies based on CR, with greater CR related to a stronger link between brain volume and cognition before, and a weaker link after, dementia diagnosis.

590    __

$a NEINDEXOVÁNO

655    _2

$a časopisecké články $7 D016428

700    1_

$a Veal, Britney M $u School of Aging Studies, University of South Florida, Tampa, FL, United States

700    1_

$a Andel, Ross $u Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, United States $u Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia

700    1_

$a Martinkova, Julie $u Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia

700    1_

$a Veverova, Katerina $u Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia

700    1_

$a Horáková, Hana, $u Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia $d 1990- $7 xx0210941

700    1_

$a Nedelska, Zuzana $u Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia

700    1_

$a Laczó, Jan $u Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia

700    1_

$a Vyhnalek, Martin $u Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia

700    1_

$a Hort, Jakub $u Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia

773    0_

$w MED00174539 $t Frontiers in aging neuroscience $x 1663-4365 $g Roč. 14, č. - (2022), s. 1018071

856    41

$u https://pubmed.ncbi.nlm.nih.gov/36408097 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y p $z 0

990    __

$a 20230119 $b ABA008

991    __

$a 20230815090959 $b ABA008

999    __

$a ok $b bmc $g 1889471 $s 1182690

BAS    __

$a 3

BAS    __

$a PreBMC-PubMed-not-MEDLINE

BMC    __

$a 2022 $b 14 $c - $d 1018071 $e 20221103 $i 1663-4365 $m Frontiers in aging neuroscience $n Front Aging Neurosci $x MED00174539

LZP    __

$a Pubmed-20230119